Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Reduced Expression of Cxcr4, a Novel Renal Cancer Stem Cell Marker, Is Associated With High-Grade Renal Cell Carcinoma Publisher Pubmed



Rasti A1 ; Abolhasani M1, 2 ; Zanjani LS1 ; Asgari M1, 2 ; Mehrazma M1, 2 ; Madjd Z1, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Hemmat Street (Highway), Next to Milad Tower, Tehran, 14496-14530, Iran
  2. 2. Hasheminejad Kidney Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Cancer Research and Clinical Oncology Published:2017


Abstract

Purpose: Cancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential. This study aimed to evaluate the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel CSC marker in renal cell carcinoma (RCC). Methods: The expression of CXCR4 was examined in 173 well-defined renal tumour tissues, including 106 (61.5 %) clear cell renal cell carcinomas (ccRCCs), 35 (20 %) papillary renal cell carcinomas (pRCCs), and 32 (18.5 %) chromophobe renal cell carcinomas (ChRCCs), by immunohistochemistry on a tissue microarray. The association between expression of this marker and clinicopathologic parameters was then analysed. Results: There was a significant difference in the expression levels of CXCR4 in the ccRCC samples compared to the ChRCC and pRCC samples (P < 0.001). Increased expression of CXCR4 was significantly correlated with higher-grade tumours (P < 0.001) and worse stage (P = 0.001). A significant association was also found between expression of CXCR4 and microvascular invasion (P = 0.018). Among RCC subtypes, comparison of the differences between CXCR4 expression in low- and high-grade tumours demonstrated that pRCC tumours had a significantly higher expression of CXCR4 (P < 0.001) than ccRCC tumours (P = 0.01). Conclusion: Significantly higher expression levels of CXCR4 were found in pRCC and ccRCC samples. Increased CXCR4 expression was associated with more aggressive tumour behaviour in RCC patients, especially in pRCC and ccRCC subtypes due to their more metastatic behaviour. These findings suggest that CXCR4 can be considered as a novel diagnostic and therapeutic marker for targeted therapy of renal carcinoma. © 2016, Springer-Verlag Berlin Heidelberg.
Related Docs
View other Related Docs
1. Cytoplasmic Expression of Twist1, an Emt-Related Transcription Factor, Is Associated With Higher Grades Renal Cell Carcinomas and Worse Progression-Free Survival in Clear Cell Renal Cell Carcinoma, Clinical and Experimental Medicine (2018)
2. Smad4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes, Frontiers in Oncology (2021)
3. Increased Expression of Cd44 Is Associated With More Aggressive Behavior in Clear Cell Renal Cell Carcinoma, Biomarkers in Medicine (2018)
4. Co-Expression of Cancer Stem Cell Markers Oct4 and Nanog Predicts Poor Prognosis in Renal Cell Carcinomas, Scientific Reports (2018)
5. Cytoplasmic Expression of Cd133 Stemness Marker Is Associated With Tumor Aggressiveness in Clear Cell Renal Cell Carcinoma, Experimental and Molecular Pathology (2017)
6. Increased Expression of Aldh1a1 in Prostate Cancer Is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients, Applied Immunohistochemistry and Molecular Morphology (2017)
7. Co-Expression of Putative Cancer Stem Cell Markers Cd44 and Cd133 in Prostate Carcinomas, Pathology and Oncology Research (2017)
8. Cancer Stem Cell Research in Iran: Potentials and Challenges, Future Oncology (2017)
Experts (# of related papers)
View all Related Experts
Arezoo Rasti (7)
Ziba Veisi Malekshahi (1)
Other Related Docs
9. Diagnostic and Prognostic Accuracy of Mir-21 in Renal Cell Carcinoma: A Systematic Review Protocol, BMJ Open (2016)
10. Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like and Invasive Characteristics, Frontiers in Oncology (2019)
11. Lgr5 High /Dclk1 High Phenotype Is More Common in Early Stage and Intestinal Subtypes of Gastric Carcinomas, Cancer Biomarkers (2017)
12. High Gd2 Expression Defines Breast Cancer Cells With Enhanced Invasiveness, Experimental and Molecular Pathology (2019)
13. Morphological and Molecular Characteristics of Spheroid Formation in Ht-29 and Caco-2 Colorectal Cancer Cell Lines, Cancer Cell International (2021)
14. Differential Expression of Cancer Stem Cell Markers Aldh1 and Cd133 in Various Lung Cancer Subtypes, Cancer Investigation (2015)
15. The Impact of Succinate Dehydrogenase Gene (Sdh) Mutations in Renal Cell Carcinoma (Rcc): A Systematic Review, OncoTargets and Therapy (2019)
16. Expression Patterns of Cxcl12 and Its Receptor in Colorectal Carcinoma, Clinical Laboratory (2018)
17. Nano-Delivery System Targeting to Cancer Stem Cell Cluster of Differentiation Biomarkers, Journal of Controlled Release (2017)
18. The Incidence and Mortality of Kidney Cancers,And Their Relationship With Human Development Index in Asia, Journal of Nephropathology (2017)
19. Expression of Cancer Stem Cell Markers Oct4 and Cd133 in Transitional Cell Carcinomas, Applied Immunohistochemistry and Molecular Morphology (2017)
20. Clinicopathological Significance of Tumor Stem Cell Markers Aldh1 and Cd133 in Colorectal Carcinoma, Iranian Journal of Pathology (2021)
21. Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review, International Journal of Stem Cells (2019)
22. The Role of Hypoxia-Inducible Factors in Breast Cancer Stem Cell Specification, Pathology Research and Practice (2023)