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Wound Healing Effects of Curcumin: A Short Review Publisher Pubmed



Tejada S1 ; Manayi A2 ; Daglia M3 ; Nabavi SF4 ; Sureda A5 ; Hajheydari Z6 ; Gortzi O7 ; Pazokitoroudi H8 ; Nabavi SM4
Authors
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Authors Affiliations
  1. 1. Experimental Laboratory, Research Unit, Son Llatzer Hospital, IUNICS, Ctra. Manacor km 4, Palma de Mallorca, Balearic Islands, E-07198, Spain
  2. 2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy
  4. 4. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Grup de Nutricio Comunitaria i Estres Oxidatiu (IUNICS), CIBEROBN Universitat de les Illes Balears, Palma de Mallorca, Spain
  6. 6. Department of Dermatology, Boo Ali Sina (Avicenna) Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Department of Food Technology, Technological Educational Institution of Thessaly, Terma N. Temponera Str., Greece
  8. 8. Physiology Research Center & Department of Physiology, Iran University of Medical Sciences, Tehran, Iran

Source: Current Pharmaceutical Biotechnology Published:2016


Abstract

Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), has been studied for many years due to its bio-functional properties, especially antioxidant, radical scavenger, antimicrobial and anti-inflammatory activities, which play a crucial role in the wound healing process. Moreover, curcumin stimulated the production of the growth factors involved in the wound healing process, and so curcumin also accelerated the management of wound restoration. The aim of the present review is collecting and evaluating the literature data regarding curcumin properties potentially relevant for wound healing. Moreover, the investigations on the wound healing effects of curcumin are reported. In order to produce a more complete picture, the chemistry and sources of curcumin are also discussed. © 2016 Bentham Science Publishers.
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