Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators

Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators Publisher Pubmed

Zadali R^{1, 2, 3} ; Nejadebrahimi S⁴ ; Hadjiakhoondi A^{2, 5} ; Fiengo L¹ ; Dambola M¹ ; De Vita S¹ ; Tofighi Z^{2, 5} ; Chini MG^{1, 6} ; Bifulco G¹ ; De Tommasi N¹

Show Affiliations

1. Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano (SA), 84084, Italy
2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3. Department of Pharmacognosy, Faculty of Pharmacy, Islamic Azad University-Damghan Branch, Iran
4. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
5. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Bioscience and Territory, University of Molise, C.da Fonte Lappone, Pesche (IS), 86090, Italy

Source: Phytochemistry Published:2021

Abstract

Four undescribed and 17 known diterpenoids were isolated from the roots of Zhumeria majdae Rech.f. & Wendelbo. Using 1D and 2D NMR spectroscopy, ECD spectroscopy, and HRESIMS data analysis, the structures of the undescribed compounds were elucidated. The anti-proliferative activity of isolated compounds was evaluated against HeLa and MCF7 cancer cell lines. The binding affinity of all compounds to HSP90, one of the targets for the modern anticancer therapy, was investigated using surface plasmon resonance. The results demonstrated that lanugon Q interacted with the chaperone. To explain its mechanism of action, experimental and computational tests were also conducted. © 2021 Elsevier Ltd

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Style	Citing Format
MLA	Zadali R, et al.. "Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators." Phytochemistry, vol. 185, no. , 2021, pp. -.
APA	Zadali R, Nejadebrahimi S, Hadjiakhoondi A, Fiengo L, Dambola M, De Vita S, Tofighi Z, Chini MG, Bifulco G, De Tommasi N (2021). Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators. Phytochemistry, 185(), -.
Chicago	Zadali R, Nejadebrahimi S, Hadjiakhoondi A, Fiengo L, Dambola M, De Vita S, Tofighi Z, Chini MG, Bifulco G, De Tommasi N. "Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators." Phytochemistry 185, no. (2021): -.
Harvard	Zadali R et al. (2021) 'Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators', Phytochemistry, 185(), pp. -.
Vancouver	Zadali R, Nejadebrahimi S, Hadjiakhoondi A, Fiengo L, Dambola M, De Vita S, et al.. Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators. Phytochemistry. 2021;185():-.
BibTex	@article{ author = {Zadali R and Nejadebrahimi S and Hadjiakhoondi A and Fiengo L and Dambola M and De Vita S and Tofighi Z and Chini MG and Bifulco G and De Tommasi N}, title = {Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators}, journal = {Phytochemistry}, volume = {185}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Zadali R AU - Nejadebrahimi S AU - Hadjiakhoondi A AU - Fiengo L AU - Dambola M AU - De Vita S AU - Tofighi Z AU - Chini MG AU - Bifulco G AU - De Tommasi N TI - Diterpenoids From Zhumeria Majdae Roots As Potential Heat Shock Protein 90 (Hsp90) Modulators JO - Phytochemistry VL - 185 IS - SP - EP - PY - 2021 ER -

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