In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines

In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines Publisher

Sabernavaei M¹ ; Montazeri H¹ ; Mirzabeigi P² ; Sharafibadr P¹ ; Zamani M¹ ; Hadjiakhoondi A³ ; Yassaa N³ ; Kobarfard F⁴

Show Affiliations

1. Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
2. Department of Clinical Pharmacy and Pharmacoeconomics, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
3. Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Natural Product Research Published:2023

Abstract

Medicinal plants such as Leutea avicennae Mozaff. (Apiaceae) have been shown some biological potential for preventing and treating diseases. Fractions and isolated compounds were tested on colon carcinoma (HT-29), cervical carcinoma (HeLa), breast carcinoma (MCF-7), and mouse embryonic fibroblast (NIH/3T3) cell lines. The BSLT method was used for the assessment of the general toxicity of the petroleum ether (PET), chloroform (CHCl3), ethyl acetate (EtOAc), and methanol (MeOH) fractions obtained from the aerial parts of L. avicennae. 1H-NMR and 13 C-NMR spectroscopy were used for structure elucidation. Five compounds, including two coumarins, osthole and umbelliferone, a diterpene phytol, β-sitosterol, and lauric acid, were isolated for the first time from L. avicennae. Osthole showed potent cytotoxic activity against MCF-7 and HT-29 cell lines with IC50 values of 4.23 ± 0.26 and 12.11 ± 0.13 µg/mL, respectively. Phytol demonstrated potent cytotoxic activity towards MCF-7 and HeLa cell lines with IC50 values of 6.80 ± 0.08 and 12.27 ± 0.18 µg/mL, respectively. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Sabernavaei M, et al.. "In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines." Natural Product Research, vol. , no. , 2023, pp. -.
APA	Sabernavaei M, Montazeri H, Mirzabeigi P, Sharafibadr P, Zamani M, Hadjiakhoondi A, Yassaa N, Kobarfard F (2023). In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines. Natural Product Research, (), -.
Chicago	Sabernavaei M, Montazeri H, Mirzabeigi P, Sharafibadr P, Zamani M, Hadjiakhoondi A, Yassaa N, Kobarfard F. "In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines." Natural Product Research , no. (2023): -.
Harvard	Sabernavaei M et al. (2023) 'In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines', Natural Product Research, (), pp. -.
Vancouver	Sabernavaei M, Montazeri H, Mirzabeigi P, Sharafibadr P, Zamani M, Hadjiakhoondi A, et al.. In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines. Natural Product Research. 2023;():-.
BibTex	@article{ author = {Sabernavaei M and Montazeri H and Mirzabeigi P and Sharafibadr P and Zamani M and Hadjiakhoondi A and Yassaa N and Kobarfard F}, title = {In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines}, journal = {Natural Product Research}, volume = {}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Sabernavaei M AU - Montazeri H AU - Mirzabeigi P AU - Sharafibadr P AU - Zamani M AU - Hadjiakhoondi A AU - Yassaa N AU - Kobarfard F TI - In-Vitro Cytotoxic Potential of Aerial Parts of Leutea Avicennae Mozaff. in Different Human Cancer Cell Lines JO - Natural Product Research VL - IS - SP - EP - PY - 2023 ER -

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