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Polycaprolactone/Gelatin Nanofibrous Scaffolds for Tissue Engineering Publisher



Farzamfar S1 ; Aleahmad M2 ; Kouzehkonan GS3 ; Salehi M4, 5, 6 ; Nazeri N3
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  6. 6. Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

Source: Biointerface Research in Applied Chemistry Published:2021


Abstract

The combined use of polycaprolactone and gelatin has obviated many drawbacks associated with applying them alone. Polycaprolactone provides mechanical strength and buys sufficient time for tissue regeneration without degradation. Simultaneously, gelatin regulates the surface wettability of the composite scaffold. It makes the structure more cytocompatible by its cell recognition sites. Furthermore, these low polymers' cost, biocompatibility, and tuning of degradation time have added to their therapeutic appeal. In the current study, we have reviewed the application of polycaprolactone/gelatin scaffolds in tissue engineering and drug delivery fields, hoping to translate these scaffolds into medicine. © 2020 by the authors.
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