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Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy Publisher Pubmed



Ahmadi Y1, 2 ; Ghorbanihaghjo A2 ; Naghizadeh M3 ; Yagin NL4
Authors

Source: Inflammopharmacology Published:2018


Abstract

Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants. © 2018, Springer International Publishing AG, part of Springer Nature.
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