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Oxidative Stress As a Possible Mechanism of Statin-Induced Myopathy Publisher Pubmed



Ahmadi Y1, 2 ; Ghorbanihaghjo A2 ; Naghizadeh M3 ; Yagin NL4
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Biochemistry and Clinical Laboratories, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Nutritional Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Inflammopharmacology Published:2018


Abstract

Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants. © 2018, Springer International Publishing AG, part of Springer Nature.
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