Association Between Acne and Serum Pro-Inflammatory Cytokines (Il-1Α, Il-1Β, Il-1Ra, Il-6, Il-8, Il-12 and Rantes) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study Pubmed



Askari N¹ ; Ghazanfari T² ; Yaraee R² ; Mahdavi MRV² ; Soroush MR³ ; Hassan ZM⁴ ; Khodashenas Z⁵ ; Shams J² ; Faghihzadeh S⁶ Show Affiliations
Source: Archives of Iranian Medicine Published:2017

Abstract

Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in sulfur mustard-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1 Ra, IL-6, IL-8, IL-12and RANTES) were measured using sandwich ELISA technique. Results: The median of serum levels of IL-1β, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1 Ra and IL-6 between the exposed subgroups. Conclusion: Wfe found a positive association between serum levels of pro-inflammatory cytokines (IL-1β, IL-8, IL-12 and RANTES) and acne among sulfur mustard-exposed population. © 2017 Academy of Medical Sciences of I.R. Iran. All rights reserved.