Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Th17/Treg Immunoregulation and Implications in Treatment of Sulfur Mustard Gas-Induced Lung Diseases Publisher Pubmed



Iman M1 ; Rezaei R2 ; Azimzadeh Jamalkandi S1 ; Shariati P3 ; Kheradmand F4 ; Salimian J1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  4. 4. Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey VA, & Department of Medicine, Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX, United States

Source: Expert Review of Clinical Immunology Published:2017


Abstract

Introduction: Sulfur mustard (SM) is an extremely toxic gas used in chemical warfare to cause massive lung injury and death. Victims exposed to SM gas acutely present with inhalational lung injury, but among those who survive, some develop obstructive airway diseases referred to as SM-lung syndrome. Pathophysiologically, SM-lung shares many characteristics with smoking-induced chronic obstructive pulmonary disease (COPD), including airway remodeling, goblet cell metaplasia, and obstructive ventilation defect. Some of the hallmarks of COPD pathogenesis, which include dysregulated lung inflammation, neutrophilia, recruitment of interleukin 17A (IL −17A) expressing CD4+T cells (Th17), and the paucity of lung regulatory T cells (Tregs), have also been described in SM-lung. Areas covered: A literature search was performed using the MEDLINE, EMBASE, and Web of Science databases inclusive of all literature prior to and including May 2017. Expert commentary: Here we review some of the recent findings that suggest a role for Th17 cell-mediated inflammatory changes associated with pulmonary complications in SM-lung and suggest new therapeutic approaches that could potentially alter disease progression with immune modulating biologics that can restore the lung Th17/Treg balance. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Tgf-Β and Th17 Cells Related Injuries in Patients With Sulfur Mustard Exposure, Journal of Cellular Physiology (2018)
2. Immunology of Chronic Obstructive Pulmonary Disease and Sulfur Mustard Induced Airway Injuries: Implications for Immunotherapeutic Interventions, Current Pharmaceutical Design (2016)
3. The Footprint of Tgf-Β in Airway Remodeling of the Mustard Lung, Inhalation Toxicology (2015)
4. Advice on Assistance and Protection Provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. on Medical Care and Treatment of Injuries From Sulfur Mustard, Toxicology (2021)
5. Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment, Acta Medica Iranica (2016)
6. Expression of Mir-15B-5P, Mir-21-5P, and Smad7 in Lung Tissue of Sulfur Mustard-Exposed Individuals With Long-Term Pulmonary Complications, Iranian Journal of Allergy# Asthma and Immunology (2019)
7. Characterization of Lung Fibroblasts More Than Two Decades After Mustard Gas Exposure, PLoS ONE (2015)
8. An Evidence-Based Review of the Genotoxic and Reproductive Effects of Sulfur Mustard, Archives of Toxicology (2017)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Jamshid Hadjati (4)
Other Related Docs
9. Risks of On-Pump Coronary Artery Bypass Grafting Surgery in Patients With Chronic Obstructive Pulmonary Disease Due to Sulfur Mustard, Postepy Dermatologii i Alergologii (2017)
10. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
11. Sp-A and Tlr4 Localization in Lung Tissue of Sm-Exposed Patients, International Immunopharmacology (2020)
12. Gastric Cancer Stem Cells Effect on Th17/Treg Balance; a Bench to Beside Perspective, Frontiers in Oncology (2019)
13. The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia, Future Oncology (2015)
14. Circulating Mesenchymal Stem Cells in Sulfur Mustard-Exposed Patients With Long-Term Pulmonary Complications, Toxicology Letters (2019)
15. Immunomodulatory Effects of Flavonoids: Possible Induction of T Cd4+ Regulatory Cells Through Suppression of Mtor Pathway Signaling Activity, Frontiers in Immunology (2019)
16. Metabolism Plays the Key Roles in Th Cells Differentiation, Reumatismo (2016)
17. Molecular Mechanisms of the Action of Vitamin a in Th17/Treg Axis in Multiple Sclerosis, Journal of Molecular Neuroscience (2015)
18. The Predictive Association Between Radiological Findings and Lung Cancer Development in Patients Exposed to Sulfur Mustard Gas: 4 Decades Follow up of 719 Victims, BMC Pulmonary Medicine (2022)
19. Emerging Therapeutic Potential of Regulatory T (Treg) Cells for Rheumatoid Arthritis: New Insights and Challenges, International Immunopharmacology (2022)
20. Crosstalk Between Autophagy and Metabolic Regulation of (Car) T Cells: Therapeutic Implications, Frontiers in Immunology (2023)
21. Efficacy and Safety of Immune Checkpoint Inhibitors and Cytokine Therapy in Autoimmune Diseases, Translational Autoimmunity: Treatment of Autoimmune Diseases (2022)
22. Targeting Hypoxia and Hypoxia-Inducible Factor-1 in the Tumor Microenvironment for Optimal Cancer Immunotherapy, Journal of Cellular Physiology (2022)
23. Investigating Prevalence and Pattern of Long-Term Cardiovascular Disorders in Sulphur Mustard-Exposed Victims and Determining Proper Biomarkers for Early Defining, Monitoring and Analysis of Patients’ Feedback on Therapy, Basic and Clinical Pharmacology and Toxicology (2017)
24. Glycolysis and Autoimmune Diseases: A Growing Relationship, Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology (2020)
25. Association Between Acne and Serum Pro-Inflammatory Cytokines (Il-1Α, Il-1Β, Il-1Ra, Il-6, Il-8, Il-12 and Rantes) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study, Archives of Iranian Medicine (2017)
26. Nanocurcumin Modulates Th17 Cell Responses in Moderate and Severe Copd Patients, Heliyon (2024)
27. Targeted Cancer Therapy: Review Article, Tehran University Medical Journal (2018)
28. A Novel Combination of Docosahexaenoic Acid, All-Trans Retinoic Acid, and 1, 25-Dihydroxyvitamin D3 Reduces T-Bet Gene Expression, Serum Interferon Gamma, and Clinical Scores But Promotes Pparγ Gene Expression in Experimental Autoimmune Encephalomyelitis, Journal of Molecular Neuroscience (2016)
29. The Levels of Exhaled Nitric Oxide in Mustard Airway Disease, Trauma Monthly (2022)
30. Histopathology Study of Patients With Delayed Mustard Gas Keratopathy 30 Years After Exposure, Iranian Journal of Pathology (2022)
31. Autoimmune Diseases, Clinical Immunology (2022)
32. Paraclinical Findings in Iranian Veterans Exposed to Sulfur Mustard Gas: A Literature Review, Chinese Journal of Traumatology - English Edition (2017)
33. Interleukin-6 Cytokine: An Overview of the Immune Regulation, Immune Dysregulation, and Therapeutic Approach, International Immunopharmacology (2022)
34. Changes in Th17 Cells Frequency and Function After Ozone Therapy Used to Treat Multiple Sclerosis Patients: Ozone Therapy Uses to Treat Multiple Sclerosis Patients, Multiple Sclerosis and Related Disorders (2020)
35. Evaluation of Mir-200C-3P and Mir-421-5P Levels During Immune Responses in the Admitted and Recovered Covid-19 Subjects, Infection# Genetics and Evolution (2022)
36. Chemical Exposure and Alveolar Macrophages Responses: 'The Role of Pulmonary Defense Mechanism in Inhalation Injuries', BMJ Open Respiratory Research (2023)
37. Tsga10 Overexpression Inhibits Angiogenesis of Huvecs: A Hif-2Α Biased Perspective, Microvascular Research (2020)
38. Il-17 and Colorectal Cancer: From Carcinogenesis to Treatment, Cytokine (2019)
39. Inhibition of Hif-1Α Enhances Anti-Tumor Effects of Dendritic Cell-Based Vaccination in a Mouse Model of Breast Cancer, Cancer Immunology# Immunotherapy (2016)
40. Metabolomics Diagnostic Approach to Mustard Airway Diseases: A Preliminary Study, Iranian Journal of Basic Medical Sciences (2018)
41. A Metabolic Switch to Memory Car T Cells: Implications for Cancer Treatment, Cancer Letters (2021)
42. Evaluation of Il-17 Producing Memory Regulatory and Effector T Cells Expressing Cd26 Molecule in Patients With Psoriasis, Iranian Journal of Allergy# Asthma and Immunology (2018)
43. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
44. F Protein Increases Cd4+Cd25+ T Cell Population in Patients With Chronic Hepatitis C, Pathogens and Disease (2015)
45. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
46. Nmr Spectroscopy-Based Metabolomic Study of Serum in Sulfur Mustard Exposed Patients With Lung Disease, Biomarkers (2017)
47. A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders, Molecular Immunology (2019)
48. The Immunomodulatory Effects of Mesenchymal Stem Cells on Long Term Pulmonary Complications in an Animal Model Exposed to a Sulfur Mustard Analog, International Immunopharmacology (2020)
49. Mesenchymal Stem Cells Induce Expansion of Regulatory T Cells in Abortion-Prone Mice, Reproduction (2021)
50. Autoimmunity As a Target for Chimeric Immune Receptor Therapy: A New Vision to Therapeutic Potential, Blood Reviews (2020)