Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions

Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions Publisher Pubmed

Karami Fath M¹ ; Akbari Oryani M² ; Ramezani A³ ; Barjoie Mojarad F⁴ ; Khalesi B⁵ ; Delazar S⁶ ; Anjomrooz M⁷ ; Taghizadeh A⁸ ; Taghizadeh S⁹ ; Payandeh Z¹⁰ ; Pourzardosht N¹¹

Show Affiliations

1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
2. Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Department of Radiology, Faculty of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5. Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization, Karaj, Iran
6. Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
8. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
10. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
11. Biochemistry Department, Guilan University of Medical Sciences, Rasht, Iran

Source: Critical Reviews in Oncology/Hematology Published:2021

Abstract

Cancer can be caused by various factors, including the malfunction of tumor suppressor genes and the hyper-activation of proto-oncogenes. Tumor-associated extrachromosomal circular DNA (eccDNA) has been shown to adversely affect human health and accelerate malignant actions. Whole-genome sequencing (WGS) on different cancer types suggested that the amplification of ecDNA has increased the oncogene copy number in various cancers. The unique structure and function of ecDNA, its profound significance in cancer, and its help in the comprehension of current cancer genome maps, renders it as a hotspot to explore the tumor pathogenesis and evolution. Illumination of the basic mechanisms of ecDNA may provide more insights into cancer therapeutics. Despite the recent advances, different features of ecDNA require further elucidation. In the present review, we primarily discussed the characteristics, biogenesis, genesis, and origin of ecDNA and later highlighted its functions in both tumorigenesis and therapeutic resistance of different cancers. © 2021

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Style	Citing Format
MLA	Karami Fath M, et al.. "Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions." Critical Reviews in Oncology/Hematology, vol. 166, no. , 2021, pp. -.
APA	Karami Fath M, Akbari Oryani M, Ramezani A, Barjoie Mojarad F, Khalesi B, Delazar S, Anjomrooz M, Taghizadeh A, Taghizadeh S, Payandeh Z, Pourzardosht N (2021). Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions. Critical Reviews in Oncology/Hematology, 166(), -.
Chicago	Karami Fath M, Akbari Oryani M, Ramezani A, Barjoie Mojarad F, Khalesi B, Delazar S, Anjomrooz M, et al.. "Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions." Critical Reviews in Oncology/Hematology 166, no. (2021): -.
Harvard	Karami Fath M et al. (2021) 'Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions', Critical Reviews in Oncology/Hematology, 166(), pp. -.
Vancouver	Karami Fath M, Akbari Oryani M, Ramezani A, Barjoie Mojarad F, Khalesi B, Delazar S, et al.. Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions. Critical Reviews in Oncology/Hematology. 2021;166():-.
BibTex	@article{ author = {Karami Fath M and Akbari Oryani M and Ramezani A and Barjoie Mojarad F and Khalesi B and Delazar S and Anjomrooz M and Taghizadeh A and Taghizadeh S and Payandeh Z and Pourzardosht N}, title = {Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions}, journal = {Critical Reviews in Oncology/Hematology}, volume = {166}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Karami Fath M AU - Akbari Oryani M AU - Ramezani A AU - Barjoie Mojarad F AU - Khalesi B AU - Delazar S AU - Anjomrooz M AU - Taghizadeh A AU - Taghizadeh S AU - Payandeh Z AU - Pourzardosht N TI - Extra Chromosomal Dna in Different Cancers: Individual Genome With Important Biological Functions JO - Critical Reviews in Oncology/Hematology VL - 166 IS - SP - EP - PY - 2021 ER -

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