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Ets Transcription Factor Elk3 in Human Cancers: An Emerging Therapeutic Target Publisher Pubmed



Alhawary SIS1 ; Pallathadka H2 ; Hjazi A3 ; Zhumanov ZE4, 5 ; Alazbjee AAA6 ; Imad S7 ; Alsalamy A8 ; Hussien BM9 ; Jaafer NS10 ; Mahmoudi R11
Authors
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Authors Affiliations
  1. 1. Department of Bussiness Adminstration, Bussiness School, Al al-Bayt University, P.O.BOX 130040, Mafraq, 25113, Jordan
  2. 2. Manipur International University, Manipur, Imphal, India
  3. 3. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  4. 4. Department of Pathological Anatomy, With a Section-biopsy Course, Samarkand State Medical Institute, Amir Temur Street 18, Samarkand, Uzbekistan
  5. 5. Department of Scientific Affairs, Tashkent State Dental Institute, Makhtumkuli Street 103, Tashkent, 100047, Uzbekistan
  6. 6. Collage of Medicin, Al-Ayen University, Thi-Qar, Iraq
  7. 7. Medical Technical College, Al-Farahidi University, Baghdad, Iraq
  8. 8. College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, 66002, Iraq
  9. 9. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  10. 10. Department of Medical Laboratory Technologies, Al Rafidain University College, Bagdad, Iraq
  11. 11. Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Cancer is a genetic and complex disorder, resulting from several events associated with onset, development, and metastasis. Tumor suppressors and oncogenes are among the main regulators of tumor progression, contributing to various cancer-related behaviors like cell proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), cell cycle, and apoptosis. Transcription factors (TFs) could act as tumor suppressors or oncogenes in cancer progression. E-twenty-six/E26 (ETS) family of TFs have a winged helix-turn-helix (HLH) motif, which interacted with specific DNA regions with high levels of purines and GGA core. ETS proteins act as transcriptional repressors or activators to modulate the expression of target genes. ETS transcription factor ELK3 (ELK3), as a type of ETS protein, was shown to enhance in various cancers, suggesting that it may have an oncogenic role. These studies indicated that ELK3 promoted invasion, migration, cell cycle, proliferation, and EMT, and suppressed cell apoptosis. In addition, these studies demonstrated that ELK3 could be a promising diagnostic and prognostic biomarker in human cancer. Moreover, accumulating data proved that ELK3 could be a novel chemoresistance mediator in human cancer. Here, we aimed to explore the overall change of ELK3 and its underlying molecular mechanism in human cancers. Moreover, we aimed to investigate the potential role of ELK3 as a prognostic and diagnostic biomarker as well as its capability as a chemoresistance mediator in cancer. © 2023 Elsevier GmbH
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