Metformin Ameliorates Cardiopulmonary Toxicity Induced by Chlorpyrifos Publisher Pubmed



Farhadi R^{1, 2} ; Daniali M^{1, 2} ; Baeeri M^{1, 2} ; Foroumadi R^{2, 3} ; Gholami M^{1, 2} ; Hassani S^{1, 2} ; Mirzababaei S² ; Haghiaminjan H⁴ ; Navaeinigjeh M^{1, 2} ; Rahimifard M^{1, 2} ; Abdollahi M^{1, 2} Show Affiliations
Source: Drug and Chemical Toxicology Published:2023

Abstract

Chlorpyrifos (CPF) is a widely used pesticide that can impair body organs. Nonetheless, metformin is known for its protective role against dysfunction at cellular and molecular levels led by inflammatory and oxidative stress. This study aimed to investigate the modulatory impacts of metformin on CPF-induced heart and lung damage. Following the treatment of Wistar rats with different combinations of metformin and CPF, plasma, as well as heart and lung tissues, were isolated to examine the level of oxidative stress biomarkers like reactive oxygen species (ROS) and malondialdehyde (MDA), inflammatory cytokines such as tumor necrosis alpha (TNF-α), high mobility group box 1 (HMGB1) gene, deoxyribonucleic acid (DNA) damage, lactate, ADP/ATP ratio, expression of relevant genes (TRADD, TERT, KL), and along with histological analysis. Based on the findings, metformin significantly modulates the impairments in heart and lung tissues induced by CPF. © 2023 Informa UK Limited, trading as Taylor & Francis Group.