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Dental Pulpal Tissue Regeneration, Pulpal Vitality Testing, and Healing of Apical Lesions Following Stem Cell Transplant: A Systematic Review and Meta-Analysis Publisher



Jamali S1 ; Mousavi E2 ; Darvish M3 ; Jabbari G4 ; Nasrabadi N5 ; Ahmadizadeh H6
Authors
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Authors Affiliations
  1. 1. Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Shaanxi, 710004, China
  2. 2. Dental Sciences Research Center, Department of Endodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Department of Endodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Endodontics, Dental School, Urmia University of Medical Sciences, Urmia, Iran
  5. 5. Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: Pesquisa Brasileira em Odontopediatria e Clinica Integrada Published:2020


Abstract

Objective: To analyze data obtained from animal and human studies using stem cells. Material and Methods: Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed, Cochrane Library, Embase, Information Sciences Institute (ISI), as well as Google Scholar were utilized and searched as available electronic databases to perform a systematic literature review of articles published between 2010 and 2019. The Endnote X9 for Windows was also employed to manage electronic titles and abstracts of the selected studies. Searches were conducted using keywords of “pulpal OR pulpal tissue OR pulpal vitality”, “regeneration”, “apical healing”, “stem cells OR progenitor cells”, and “mediated pulpal tissue”. Consequently, 189 titles and abstracts endowed with potential relevance were discovered based on searches into manual and electronic sources. Ultimately, a total of six articles met the inclusion criteria in the present systematic review and meta-analysis. Results: Out of the six articles identified and selected, five studies were categorized as animal experiments and one article was nominated as a human clinical trial. The greatest bias risks were accordingly observed in the majority of animal examinations, but articles related to humans revealed decreased risks of bias, while the human clinical trial showed some concerns. Conclusion: Promising parameters testing functional pulp regeneration could be represented through stem cell transplants. © 2020, Association of Support to Oral Health Research (APESB). All rights reserved.
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