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The Potential Use of Bacteriophages As Antibacterial Agents in Dental Infection Publisher Pubmed



Hosseini Hooshiar M1 ; Salari S2 ; Nasiri K3 ; Salim US4 ; Saeed LM5 ; Yasamineh S6 ; Safaralizadeh R7
Authors
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Authors Affiliations
  1. 1. Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Doctor of Dental Surgery, Islamic Azad University of Medical Sciences, Esfahan, Iran
  3. 3. Department of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dentistry, Al-Noor University College, Nineveh, Iraq
  5. 5. Collage of Dentist, National University of Science and Technology, Dhi Qar, 64001, Iraq
  6. 6. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  7. 7. Restorative Dentistry Department of Dental Faculty, TABRIZ Medical University, Tabriz, Iran

Source: Virology Journal Published:2024


Abstract

Dental infections, such as apical Periodontitis, periodontitis, and peri-implantitis (PI), are closely associated with specific bacterial species, including Streptococcus mutans (S. mutans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum), among others. Antibiotics are extensively utilized for prophylactic and therapeutic purposes in the treatment of dental infections and other dental-related issues. Unfortunately, the rapid emergence of antimicrobial resistance has accompanied the increased use of antibiotics in recent years. Specific bacterial pathogens have reached a critical stage of antibiotic resistance, characterized by the proliferation of pan-resistant strains and the scarcity of viable therapeutic alternatives. Therapeutic use of particular bacteriophage (phage) particles that target bacterial pathogens is one potential alternative to antibiotics that are now being seriously considered for treating bacterial illnesses. A kind of virus known as a phage is capable of infecting and eliminating bacteria. Because they can’t infect cells in plants and animals, phages might be a harmless substitute for antibiotics. To control oral disorders including periodontitis and dental caries, several research have been conducted in this area to study and identify phages from human saliva and dental plaque. The capacity of these agents to disturb biofilms expands their effectiveness against dental plaque biofilms and oral pathogens in cases of periodontitis, PI, and apical periodontitis. This review summarizes the current antibacterial properties of phages used to treat a variety of dental infections, such as periodontitis, peri-implantitis, infected dentin, and apical periodontitis. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
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