Recent Advances in Treatment Crimean–Congo Hemorrhagic Fever Virus: A Concise Overview Publisher Pubmed



Gholizadeh O^{1, 2, 3} ; Jafari MM⁴ ; Zoobinparan R⁵ ; Yasamineh S⁶ ; Tabatabaie R⁷ ; Akbarzadeh S⁸ ; Amini P¹ ; Eslami M^{9, 10} ; Yousefi B¹¹ ; Dadashpour M^{11, 12} Show Affiliations
Source: Microbial Pathogenesis Published:2022

Abstract

The Crimean Congo Hemorrhagic Fever Virus (CCHFV) is widespread in Africa, Asia, and Europe, among other places. The disease was initially discovered in the Crimean cities of the Soviet Union and the Congo, and it was given the name Crimean Congo because it induces hemorrhagic fever. According to studies, when the virus enters the body, it settles in immune cells such as macrophages and dendritic cells, causing them to malfunction and secrete inflammatory cytokines such as TNF-alpha, IL1, and IL6, resulting in cytokine storms that induces shock via endothelial activation and vascular leakage, while on the other hand, clots and disseminated intravascular coagulation (DIC) formation causes massive defects in various organs such as the liver and kidneys, as well as fatal bleeding. Disease prevention and treatment are crucial since no other effective vaccination against the disease has yet been developed. Immunotherapy is utilized as a consequence. One of the most effective treatments, when combined with compensatory therapies such as blood and platelet replacement, water, electrolytes, Fresh Frozen Plasma (FFP) replacement, and other compensatory therapies, is one of the most effective treatments. Studies; show that immunotherapy using IVIG and neutralizing and non-neutralizing monoclonal antibodies; cytokine therapy, and anti-inflammatory therapy using corticosteroids are effective ways to treat the disease. © 2022