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Increased Levels of Serum and Tissue Mir-107 in Human Gastric Cancer: Correlation With Tumor Hypoxia Publisher Pubmed



Ayremlou N1 ; Mozdarani H1 ; Mowla SJ2 ; Delavari A3
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Biomarkers Published:2015


Abstract

BACKGROUND: MicroRNAs can function as oncogenes and tumor suppressor genes in human cancers. The expression of miR-107 is high in various types of solid tumors. OBJECTIVE: The aim of this study was to evaluate the tumor and serum level of miR-107 and its correlation to HIF-1α expression in gastric cancer patients. METHODS: Quantitative real-time PCR was used to analyze the expression of miR-107 and HIF-1α in 36 pairs of fresh gastric cancer and matched adjacent normal tissue specimens and the serum of these patients compared to age matched controls. RESULTS: The expression level of miR-107 was significantly higher in tumor tissues compared to adjacent normal tissue (p 0.04). For serum, the expression level of miR-107 was significantly higher in gastric cancer patients than in age matched controls (p 0.04). The correlation between tumor and serum expression of miR-107 with tumor hypoxia was found to be significant (p≤ 0.001). CONCLUSION: The overexpression of miR-107 in tumors and serum of gastric cancer patients and its correlation with HIF-1α expression in tumor tissues was indicated that miR-107 may have a potential to use as a biomarker for detection of gastric cancer patients and hypoxia in gastric cancer tumor. © 2015 - IOS Press and the authors. All rights reserved.
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