Emerging Molecular Functions of Microrna-9: Cancer Pathology and Therapeutic Implications Publisher Pubmed



Tapeh BEG^{1, 2, 3} ; Mosayyebi B⁵ ; Mansoori B¹ ; Gravand ZA⁶ ; Sarvnaz H⁴ ; Mohammadi A^{1, 7}
Source: Anti-Cancer Agents in Medicinal Chemistry Published:2021

Abstract

MiRNAs that are characterized by small non-coding RNAs orchestrate the expression of important genes involved in cancer cell development processes, including apoptosis, proliferation, angiogenesis, metasta-sis, and drug resistance at the post-transcriptional level. Dysregulation of miR-9 in various cancers has been re-ported. Recently, miR-9 has been considered as a key miRNA in various malignancies. However, its impor-tance in the pathogenesis of different neoplasms is not yet well defined. Accordingly, this study was conducted in order to clarify the potential roles of miR-9 in the development of various cancers, prognosis, and treatment approaches. We have shown that a large number of miR-9 targets play fundamental roles in carcinogenesis, and that is dysregulated in various cancer cells. Our findings werefound aberrant miR-9 expression in a majority of cancers. This review article generally emphasizesthe critical roles of miR-9 in cancer cell progression. Addition-ally, we intended to investigate the effects of down-regulation or up-regulation of miR-9 in different types of cancers. It is hoped that a good understanding of the regulatory roles of miR-9 in various cancers ishelpful for using miR-9 in clinical settings, including prognosis, diagnosis, and miRNA-based target therapy. © 2021 Bentham Science Publishers.