Anti-Inflammatory and Anti-Nociceptive Effects of Cinnamon and Clove Essential Oils Nanogels: An in Vivo Study Publisher Pubmed



Esmaeili F¹ ; Zahmatkeshan M^{2, 3} ; Yousefpoor Y⁴ ; Alipanah H⁵ ; Safari E⁶ ; Osanloo M⁷ Show Affiliations
Source: BMC Complementary Medicine and Therapies Published:2022

Abstract

Background: Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods: This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results: The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion: The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases. © 2022, The Author(s).