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Active Uveitis Induces Transient Refractive Error Changes; [活动性葡萄膜炎引起暂时性屈光度变化] Publisher



Zameni M1 ; Nikkhah H1, 2 ; Rahmani S3 ; Ramezani A4 ; Yaseri M1, 5 ; Soheilian M1, 6
Authors
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Authors Affiliations
  1. 1. Ophthalmic Research Center, Labbafinejad Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1666673111, Iran
  2. 2. Department of Ophthalmology, Torfeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 1149847514, Iran
  3. 3. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical University, Boston, 60611, United States
  4. 4. Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1666673111, Iran
  5. 5. Department of Epidemiology and Biostatics, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  6. 6. Negah Eye Hospital, Tehran, 1544914599, Iran

Source: International Eye Science Published:2019


Abstract

AIM: To evaluate the impact of active uveitis on refractive error changes. METHODS: A prospective cohort study was conducted on 66 patients (88 eyes) with active uveitis. The subjects were classified based on the anatomical location of their disease activity as anterior, intermediate, posterior and pan-uveitis. Cycloplegic refraction was performed in both active and quiescent phases, and the results were compared. RESULTS: Spherical changes in active anterior non-granulomatous uveitis resulted in an average of -0.25 (0.77) D (95% CI: -0.5 to 0) shift toward myopia (P=0.039) and in active intermediate uveitis, an average of +0.39 (0.8) D (95% CI: 0.09-0.69) shift toward hyperopia (P=0.003). Spherical equivalent changes in active intermediate uveitis resulted in hyperopic shift [+0.43 (0.94) D, 95% CI: 0.08-0.79, P=0.005]. Cylinder had only significant changes in pan-uveitis [-0.3 (0.39) D, 95% CI: -0.58 to -0.02, P=0.043]. In multivariate analysis, we noted that course of disease activity (acute versus recurrent) and anatomical location of disease activity had statistically significant effects on spherical equivalent changes (P=0.003 and P=0.004, respectively). CONCLUSION: Active uveitis has a significant effect on the refractive status of the eye, the changes of which depend on the inflamed anatomical area. Copyright 2019 by the IJO Press.