Corneal Cross-Linking Combined With Intracorneal Ring Segments Publisher



Mohammadpour M¹ ; Khorraminejad M² Show Affiliations
Source: Keratoconus: Optical and Surgical Management Published:2024

Abstract

This chapter explores the combination of corneal collagen cross-linking (CXL) and intracorneal ring segments (ICRS) for the treatment of keratoconus and corneal ectasia. It reviews various approaches to combining these treatments, including ICRS followed by CXL, simultaneous ICRS and CXL, and CXL followed by ICRS. The authors evaluate visual, refractive, and keratometric outcomes from multiple studies, comparing different sequences and timings of the combined procedures. Most studies demonstrate improvements in visual acuity, refractive error, and corneal topography with combination approaches compared to either treatment alone. While some studies suggest slight advantages to certain sequences, many find no significant differences between various combination methods. Overall, combining CXL with ICRS appears to be a safe and effective strategy for managing keratoconus, offering both corneal stabilization and visual rehabilitation. However, the authors note that further research is needed to establish standardized protocols and optimize the timing and sequence of these combined treatments. © 2025 selection and editorial matter, Mehrdad Mohammadpour and Masoud Khorrami-Nejad; individual chapters, the contributors.