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Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review Publisher Pubmed



Kermanshahi S1 ; Ghanavati G1 ; Abbasimesrabadi M1 ; Gholami M2 ; Ulloa L3 ; Motaghinejad M1 ; Safari S1
Authors
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Authors Affiliations
  1. 1. Razi Drug Research Center, Iran University of Medical Sciences, Hemmat highway, Beside the Milad Tower, P.O. Box: 14496-14525, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University, Durham, NC, United States

Source: Neurochemical Research Published:2020


Abstract

Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Recent studies reported that crocin, a carotenoid chemical compound common in crocus and gardenia flowers, has protective effects in neurodegenerative disorders due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties in the nervous system. This article reviews the new experimental, clinical, and pharmacological studies on the neuroprotective properties of crocin and its potential mechanisms to modulate metabolic oxidative stress and inflammation in neurodegenerative disorders. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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