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Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A Literature Review Publisher



Fallahi MS1 ; Zerangian N2 ; Ghorbani A3 ; Erabi G4 ; Shirali M1 ; Shabani E5 ; Rommasi F6, 7 ; Najafabadi MM8 ; Karbasi S8 ; Toutounchian S1 ; Ahangarsirous R9 ; Motaghy A10 ; Heidari M3 ; Deravi N11
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Health Education and Health Promotion, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran
  4. 4. Student Research Committee, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  5. 5. Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  6. 6. Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran, Iran
  7. 7. Microbiology Research Center(MRC), Pasteur Institute of Iran, Tehran, Iran
  8. 8. Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Faculty of Medicine, Riga Stradins University, 16 Dzirciema Street, Riga, LV-1007, Latvia
  11. 11. Student Research committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Current Cancer Therapy Reviews Published:2024


Abstract

Non-Hodgkin lymphoma (NHL) occurs in the lymphatic system because of lymphocytes tumor. This type of tumor has a high death rate among patients. In recent years, a lot of progress has been made based on understanding its exact biology; several treatment methods have been developed. Many patients are cured by a combination of different chemotherapies, despite their toxic effects. In recent years, despite various studies on monoclonal antibodies for non-Hodgkin lymphoma, there have been no narrative articles in this field. Therefore, combining monoclonal antibodies with chemotherapy is successful as they reduce the toxic side effects of chemotherapies. These antibodies can target specific cellular pathways of the immune system leading to limitation of cancer progression. In this article, various types of monoclonal antibodies, their underlying mechanisms of action, as well as their effects on patients with different phases and types of Non-Hodgkin lymphoma have been reviewed for a better understanding. © 2024 Bentham Science Publishers.
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