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Combined Therapy of Adipose-Derived Stem Cells and Photobiomodulation on Accelerated Bone Healing of a Critical Size Defect in an Osteoporotic Rat Model Publisher Pubmed



Asgari M1 ; Gazor R2 ; Abdollahifar MA1 ; Fadaei Fathabady F1 ; Zare F1 ; Norouzian M1 ; Amini A1 ; Khosravipour A1 ; Kiani P3 ; Atashgah RB4 ; Rezaei F5 ; Ghoreishi SK6 ; Chien S7 ; Hamblin MR8, 9 Show All Authors
Authors
  1. Asgari M1
  2. Gazor R2
  3. Abdollahifar MA1
  4. Fadaei Fathabady F1
  5. Zare F1
  6. Norouzian M1
  7. Amini A1
  8. Khosravipour A1
  9. Kiani P3
  10. Atashgah RB4
  11. Rezaei F5
  12. Ghoreishi SK6
  13. Chien S7
  14. Hamblin MR8, 9
  15. Bayat M1, 7
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Anatomy, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran
  4. 4. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
  5. 5. University of Kentucky College of Pharmacy, 789 South Limestone, Lexington, 40536, KY, United States
  6. 6. Department of Statistics, Qom University, Qom, Iran
  7. 7. Price Institute of Surgical Research, University of Louisville, Noveratech LLC, Louisville, KY, United States
  8. 8. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, United States
  9. 9. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

Source: Biochemical and Biophysical Research Communications Published:2020


Abstract

We investigated the impact of human demineralized bone matrix (hDBM) plus adipose-derived stem cells (hADS) plus photobiomodulation (PBM) on a critical-sized femoral defect (CSFD) in ovariectomy induced osteoporosis in rats. There were 6 groups as follows. In group 1 (control, C), only CSFDs were created. Groups 2–6 were implanted with DBM into the CSFD (DBM-CSFD). In group 2 (S), only DBM was transplanted into the CSFD. In group 3 (S + PBM), the DBM-CSFDs were treated with PBM. In group 4, the DBM-CSFDs were treated with alendronate (S + ALN). In group 5, ADSs were seeded into DBM-CSFD (S + ADS). In group 6, ADSs were seeded into DBM-CSFD and the CSFDs were treated with PBM (S + PBM + ADS). At week eight (catabolic phase of bone repair), the S + ALN, S + PBM + ADS, S + PBM, and S + ADS groups all had significantly increased bone strength than the S group (ANOVA, p = 0.000). The S + PBM, S + PBM + ADS, and S + ADS groups had significantly increased Hounsfield unit than the S group (ANOVA, p = 0.000). ALN, ADS, and PBM significantly increased healed bone strength in an experimental model of DBM-treated CSFD in the catabolic phase of bone healing in osteoporotic rats. However, ALN alone and PBM plus ADS were superior to the other protocols. © 2020 Elsevier Inc.
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