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Targeting Stats in Neuroinflammation: The Road Less Traveled! Publisher Pubmed



Nabavi SM1 ; Ahmed T2 ; Nawaz M2 ; Devi KP3 ; Balan DJ3 ; Pittala V4 ; Arguellescastilla S5 ; Testai L6 ; Khan H7 ; Sureda A8 ; De Oliveira MR9 ; Vacca RA10 ; Xu S11 ; Yousefi B12, 13 Show All Authors
Authors
  1. Nabavi SM1
  2. Ahmed T2
  3. Nawaz M2
  4. Devi KP3
  5. Balan DJ3
  6. Pittala V4
  7. Arguellescastilla S5
  8. Testai L6
  9. Khan H7
  10. Sureda A8
  11. De Oliveira MR9
  12. Vacca RA10
  13. Xu S11
  14. Yousefi B12, 13
  15. Curti V14
  16. Daglia M14
  17. Sobarzosanchez E15, 16
  18. Filosa R17
  19. Nabavi SF1, 18
  20. Majidinia M19
  21. Dehpour AR20, 21
  22. Shirooie S22
Show Affiliations
Authors Affiliations
  1. 1. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan
  3. 3. Department of Biotechnology, Alagappa University (Science Campus), Karaikudi, 630 003, Tamil Nadu, India
  4. 4. Department of Drug Sciences, University of Catania, Viale A. Doria 6, Catania, 95125, Italy
  5. 5. Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain
  6. 6. Department of Pharmacy, University of Pisa, Pisa, via Bonanno 6 - 56126, Pisa, Italy
  7. 7. Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan
  8. 8. Research Group on Community Nutrition and Oxidative Stress and CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, Palma de Mallorca, E-07122, Spain
  9. 9. Department of Chemistry/ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Correa da Costa, 2367, Cuiaba, 78060-900, MT, Brazil
  10. 10. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, I-70126, Italy
  11. 11. University of Rochester, Aab Cardiovascular Research Institute, Rochester, 14623, NY, United States
  12. 12. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  13. 13. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  14. 14. Department of Drug Sciences, University of Pavia, Pavia, Italy
  15. 15. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Spain
  16. 16. Instituto de Investigacion e Innovacion en Salud, Universidad Central de Chile, Facultad de Ciencias de la Salud, Santiago, Chile
  17. 17. Consorzio Sannio Tech, Appia Str, Apollosa, 82030, BN, Italy
  18. 18. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  19. 19. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
  20. 20. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  21. 21. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  22. 22. Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Pharmacological Research Published:2019


Abstract

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. The ability to diminish the STAT-induced transcription of inflammatory genes is documented for both natural compounds (such as polyphenols) and chemical drugs. Among polyphenols, quercetin and curcumin directly inhibit STAT, while Berberis vulgaris L. and Sophora alopecuroides L extracts act indirectly. Also, the Food and Drug Administration has approved several JAK/STAT inhibitors (direct or indirect) for treating inflammatory diseases, indicating STAT can be considered as a therapeutic target for neuroinflammatory pathologies. Considering the encouraging data obtained so far, clinical trials are warranted to demonstrate the effectiveness and potential use in the clinical practice of STAT inhibitors to treat inflammation-associated neurodegenerative pathologies. © 2018 Elsevier Ltd
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