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The Intricate Role of Mir-155 in Carcinogenesis: Potential Implications for Esophageal Cancer Research Publisher Pubmed



Narimansalehfam Z1 ; Saadatian Z2 ; Daraei A3 ; Mansoori Y4 ; Bastami M5, 6 ; Tavakkolibazzaz J7
Authors
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Authors Affiliations
  1. 1. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  4. 4. Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  5. 5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomarkers in Medicine Published:2019


Abstract

MiRNAs have immerged as essential modulators of key cellular procuresses involved in post-transcriptional regulation of the human transcriptome. They are essential components of complex regulatory networks that modulate most important physiological functions of cells. MicroRNA-155 (miR-155) is a multifaceted regulator of cell proliferation, cell cycle, development, immunity and inflammation that plays pivotal, and sometimes contradictory, roles in numerous cancers including esophageal cancer. Here, we review the intricate role of miR-155 in cancer by exemplifying carcinogenesis of various tumors, focusing on recent findings that may provide a link between miR-155 and esophageal cancer-related pathways. © 2019 Future Medicine Ltd.
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