Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity

Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity Publisher Pubmed

Karimizandi L¹ ; Zahmatkesh M^{1, 2} ; Hassanzadeh G¹ ; Hosseinzadeh S¹

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1. Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Cognitive Sciences and Behavioral Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Cytokine Published:2022

Abstract

Background: Fractalkine (CX3CL1) is a key chemokine, affects neuronal cell communication and involves in Alzheimer's disease pathogenesis. Microvesicles (MVs) participate in neuronal cells’ cross-talk in physiological and pathological states. Microvesicles released in cerebrospinal fluid (CSF) may provide a valuable footprint of brain changes. Little information is available regarding the release of fractalkine-positive MVs (CX3CL1+ -MVs) in the nervous system. Methods: We induced cognitive impairment by bilateral injection of amyloid-beta (Aβ) into the cerebral ventricles. We analyzed the CSF by flow cytometry in two experiments (trained and untrained) to elucidate the presence of CX3CL1+ -MVs. The hippocampal TNF-α as an inflammatory factor was assessed by immunohistochemistry. Results: The Aβ induced spatial memory impairment after two weeks, verified by a decrease in the escape latency in Morris water maze test. It caused an increase in the anxiety-like behaviors demonstrated by a decrease in entries into the open arms of elevated plus maze test. The Aβ increased the percent of the positive area for TNF-α staining. Histological evaluation of the hippocampus confirmed the tissue injuries. The CSF levels of CX3CL1+ -MVs, increased 2 and 7 days after Aβ injection. The Aβ increased the TNF-α staining and provided an inflammatory context to facilitate the MVs release. The rise of CX3CL1+ -MVs was transient and subsided after two weeks. Both trained and untrained experiments showed a similar rise pattern of CX3CL1+ -MVs. Conclusion: Increase of fractalkine-positive microvesicles preceded the cognitive impairment, more studies are required to approve the CX3CL1+ -MVs as a potential biomarker in the early diagnosis of Alzheimer's disease. © 2022 Elsevier Ltd

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Maryam Zahmatkesh (8)

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Style	Citing Format
MLA	Karimizandi L, et al.. "Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity." Cytokine, vol. 160, no. , 2022, pp. -.
APA	Karimizandi L, Zahmatkesh M, Hassanzadeh G, Hosseinzadeh S (2022). Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity. Cytokine, 160(), -.
Chicago	Karimizandi L, Zahmatkesh M, Hassanzadeh G, Hosseinzadeh S. "Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity." Cytokine 160, no. (2022): -.
Harvard	Karimizandi L et al. (2022) 'Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity', Cytokine, 160(), pp. -.
Vancouver	Karimizandi L, Zahmatkesh M, Hassanzadeh G, Hosseinzadeh S. Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity. Cytokine. 2022;160():-.
BibTex	@article{ author = {Karimizandi L and Zahmatkesh M and Hassanzadeh G and Hosseinzadeh S}, title = {Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity}, journal = {Cytokine}, volume = {160}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Karimizandi L AU - Zahmatkesh M AU - Hassanzadeh G AU - Hosseinzadeh S TI - Increment of Csf Fractalkine-Positive Microvesicles Preceded the Spatial Memory Impairment in Amyloid Beta Neurotoxicity JO - Cytokine VL - 160 IS - SP - EP - PY - 2022 ER -

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