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Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review Publisher Pubmed



Karimihaghighi S1, 2 ; Chavoshinezhad S3 ; Mozafari R2 ; Noorbakhsh F4, 5 ; Borhanihaghighi A1 ; Haghparast A2
Authors
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Authors Affiliations
  1. 1. Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. Box: 19615-1178, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran

Source: Cellular and Molecular Neurobiology Published:2023


Abstract

Substance abuse is one of the significant problems in social and public health worldwide. Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive drugs are primarily attributed to their ability to change dopamine signaling in the reward circuit. However, the roles of classic neurotransmitters, especially dopamine and neuromodulators, monoamines, and neuropeptides, in reinforcing characteristics of abused drugs have been extensively investigated. It has recently been revealed that central immune signaling includes cascades of chemokines and proinflammatory cytokines released by neurons and glia via downstream intracellular signaling pathways that play a crucial role in mediating rewarding behavioral effects of drugs. More interestingly, inflammatory responses in the central nervous system modulate the mesolimbic dopamine signaling and glutamate-dependent currents induced by addictive drugs. This review summarized researches in the alterations of inflammatory responses accompanied by rewarding and reinforcing properties of addictive drugs, including cocaine, methamphetamine, and opioids that were evaluated by conditioned place preference and self-administration procedures as highly common behavioral tests to investigate the motivational and reinforcing impacts of addictive drugs. Graphical Abstract: [Figure not available: see fulltext.] The neuroinflammatory responses affect the rewarding properties of psychostimulants and opioids. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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