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Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management Publisher Pubmed



Aminyavari S1 ; Afshari AR2 ; Ahmadi SS3 ; Kesharwani P4 ; Sanati M5, 6 ; Sahebkar A7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Basic Sciences, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad ‎University, Mashhad, Iran
  3. 3. Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India
  5. 5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
  6. 6. Experimental and Animal Study Center, Birjand University of Medical Sciences, Birjand, Iran
  7. 7. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Psychiatric Research Published:2024


Abstract

Alzheimer's disease (AD) is a devastating kind of dementia that is becoming more common worldwide. Toxic amyloid-beta (Aβ) aggregates are the primary cause of AD onset and development. Superparamagnetic iron oxide nanoparticles (SPIONs) have received a lot of interest in AD therapy over the last decade because of their ability to redirect the Aβ fibrillation process and improve associated brain dysfunction. The potential diagnostic application of SPIONs in AD has dramatically increased this interest. Furthermore, surface-modified engineered SPIONs function as drug carriers to improve the efficacy of current therapies. Various preclinical and clinical studies on the role of SPIONs in AD pathology have produced encouraging results. However, due to their physicochemical properties (e.g., size, surface charge, and particle concentration) in the biological milieu, SPIONs may play the role of a preventive or accelerative agent in AD. Even though SPIONs are potential therapeutic and diagnostic options in AD, significant efforts are still needed to overcome the inconsistencies and safety concerns. This review evaluated the current understanding of how various SPIONs interact with AD models and explored the discrepancies in their efficacy and safety. © 2024 Elsevier Ltd
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