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Association of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio With Tumoral Differentiation in Colorectal Cancer Publisher



Talebi V1, 2 ; Hashemi MG3 ; Ghazanfari R4 ; Tabrizi M5 ; Saleh M6 ; Saatian M7
Authors
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Authors Affiliations
  1. 1. Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Department of Radiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Prosthodontics Department, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pathology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Gene Reports Published:2022


Abstract

Introduction: Colorectal cancer is a global health issue associated with high rates of recurrence and metastasis. Inflammation plays a vital role in the pathogenesis and progression of colorectal cancer. This study aimed to determine the relationship between simple blood biomarkers namely neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) reflecting inflammatory status with histopathologic variables in CRC. Methods: The collected data in 64 patients with diagnosis of colorectal cancer operated between 2014 and 2017 were retrospectively analyzed. The relationship of the NLR and PLR with histopathologic features was evaluated. Results: In this study, the patients evaluated for histopathologic characteristics, tumoral differentiation were mild (36 %), moderate (31 %) and poor (33 %). High NLR and PLR were significantly associated with poor tumor differentiation (ƿ = 0.01 and ƿ = 0.02 respectively). Conclusion: Our findings indicate a significant relationship between these two inflammatory indices and poor tumor differentiation, but no association was found with other pathological variables. These inflammatory markers can be introduced as useful biomarkers and contribute to a more accurate classification of CRC patients. © 2022
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