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The Effect of a Garlic Supplement on the Pro-Inflammatory Adipocytokines, Resistin and Tumor Necrosis Factor-Alpha, and on Pain Severity, in Overweight or Obese Women With Knee Osteoarthritis Publisher Pubmed



Dehghani S1 ; Alipoor E2 ; Salimzadeh A3 ; Yaseri M4 ; Hosseini M4 ; Feinlebisset C5, 6 ; Hosseinzadehattar MJ1, 2, 5, 6
Authors
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Authors Affiliations
  1. 1. Department of Nutrition and Biochemistry, School of Public Health, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Rheumatology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. National Health and Medical Research Council of Australia (NHMRC), Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia
  6. 6. Discipline of Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia

Source: Phytomedicine Published:2018


Abstract

Background: Osteoarthritis (OA) is a prevalent degenerative joint disease, which is associated with chronic and disabling pain. The adipocytokines, resistin and tumor necrosis factor-alpha (TNF-α), might play a role in OA pathogenesis and outcomes. Purpose: The aim of this study was, therefore, to assess the anti-inflammatory and analgesic effects of a garlic supplement on serum resistin and TNF-α concentrations and on pain severity in overweight or obese women with knee OA. Study design: Randomized, double-blind, placebo-controlled, parallel-design trial. Methods: In this study, 80 post-menopausal overweight or obese women (25 ≤ BMI ≤ 40 kg/m2, age 50–75 years) with mild to moderate knee OA were enrolled. Patients were randomly divided into two groups to receive twice-daily either garlic tablets (total: 1000 mg) or placebo for 12 weeks. The primary outcome measures were fasting serum concentrations of resistin and TNF-α and pain severity (assessed using 0–10 point visual analogue scale (VAS)). Results: At week 12, resistin concentrations were significantly decreased in the garlic group (6.41 ± 2.40 to 5.56 ± 2.16 ng/ml; P = 0.008). Serum TNF-α levels did not change significantly within or between the two groups. Pain scores were significantly reduced in the garlic (6.8 ± 2 to 5.3 ± 2.3; P = 0.002), but not in the placebo (6.7 ± 2.4 to 6.2 ± 2.5; P = 0.674), group. Pain scores were also significantly lower in the garlic, compared with the placebo, group following supplementation (5.3 ± 2.3 vs. 6.2 ± 2.5; P = 0.043). Conclusions: The findings suggest that garlic supplementation for 12 weeks might reduce pain severity in overweight or obese women with knee OA, which may, at least in part, be mediated via a reduction in the pro-inflammatory adipocytokine, resistin. © 2018 Elsevier GmbH
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1. The Effect of 12-Week Garlic Supplementation on Symptom Relief in Overweight or Obese Women With Knee Osteoarthritis, International Journal of Clinical Practice (2018)
2. Protective Effect of Ginger (Zingiber Officinale Roscoe) Extract Against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1Β in Cultured Chondrocytes, Cells Tissues Organs (2017)
3. Possible Association Between Circulating Ctrp3 and Knee Osteoarthritis in Postmenopausal Women, Aging Clinical and Experimental Research (2019)
4. Principal Component Analysis of Adipocytokines and Insulin Associate With Risk Factors of Cardiovascular Diseases, BMC Research Notes (2020)
5. Potentially Effective Natural Drugs in Treatment for the Most Common Rheumatic Disorder: Osteoarthritis, Rheumatology International (2015)
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