Tehran University of Medical Sciences

Science Communicator Platform

Share By
Repetitive Transcranial Magnetic Stimulation for the Treatment of Lower Limb Dysfunction in Patients Poststroke: A Systematic Review With Meta-Analysis Publisher Pubmed



Ghayournajafabadi M1 ; Memari AH2 ; Hosseini L2 ; Shariat A2 ; Cleland JA3
Authors

Source: Journal of Stroke and Cerebrovascular Diseases Published:2019


Abstract

Purpose: To investigate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in recovery of lower limb dysfunction in patients poststroke. Participants and Methods: Cochrane Central Register of Controlled Trials, Medline, ISI web of knowledge, EBSCO, Embase, Cumulative Index to Nursing and Allied Health Literature and Scopus. Results: Fifteen trials with 385 patients were included. Results showed that rTMS had a significant effect on balance (standard mean difference [SMD] = .38; 95% confidence interval [CI], .07: .69; I2 = 51%) and mobility (SMD: −.67; 95% CI, −1.08: −.26; I2 = 72%). However, rTMS had no significant immediate effects on the lower limb subscale of the Fugl-Meyer Assessment (FMA-L) (SMD = .01; 95% CI, −.29: .31; I2 = 0%). Continued effects of rTMS was also found to be significant during the follow-up period (SMD = .46; 95% CI, .09: .84; I2 = 14%). Conclusion: rTMS was found to result in positive effects on mobility, balance and long-term prognosis of FMA-L. However data indicated that there is insufficient evidence for the effectiveness of rTMS in improving lower limb function. © 2019
Related Docs
View other Related Docs
1. Effects of Repetitive Transcranial Magnetic Stimulation on Lower Extremity Spasticity and Motor Function in Stroke Patients, Disability and Rehabilitation (2016)
2. Effectiveness of Repetitive Transcranial Magnetic Stimulation (Rtms) Add-On Therapy to a Standard Treatment in Individuals With Multiple Sclerosis and Concomitant Symptoms of Depression—Results From a Randomized Clinical Trial and Pilot Study, Journal of Clinical Medicine (2023)
3. A Pilot Study on the Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation on Lower Extremity Spasticity and Motor Neuron Excitability in Patients After Stroke, Journal of Bodywork and Movement Therapies (2015)
Experts (# of related papers)
View all Related Experts
Soofia Naghdi Dorbati (2)
Ahmad Ali Noorbala Tafti (2)
Other Related Docs
4. Assessing the Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Obsessive- Compulsive Disorder, Clinical EEG and Neuroscience (2022)
5. Effects of Routine Repetitive Transcranial Magnetic Stimulation on the Sleep Duration of Patients With Treatment-Resistant Depression: A Prospective Cohort Study, Psychiatry and Clinical Neurosciences Reports (2024)
6. Efficacy of Transcranial Magnetic Stimulation in Anorexia Nervosa: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2025)
7. A Randomized Controlled Trial of the Effect of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex on Lower Extremity Spasticity in Hereditary Spastic Paraplegia, Journal of Clinical Neurophysiology (2023)
8. Efficacy and Safety of Stereotactic Radiosurgery for Foramen Magnum Meningiomas: A Systematic Review and Meta-Analysis, Journal of Neurosurgical Sciences (2025)
9. Noninvasive Brain Stimulation in Alcohol Craving: A Systematic Review and Meta-Analysis, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2020)
10. The Impact of Repetitive Transcranial Magnetic Stimulation on Affected and Unaffected Sides of a Child With Hemiplegic Cerebral Palsy, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society# EMBS (2018)
11. Accelerated Repetitive Transcranial Magnetic Stimulation in the Treatment of Depressive Disorder Resistant to a Course of Antidepressant Medication, Annals of General Psychiatry (2025)