Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells

Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells Publisher

Pakdel FD^{1, 2} ; Pakdel JD³ ; Tayebi L⁴ ; Keramatipour M² ; Vodjgani M¹

Show Affiliations

1. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3. Department of Pharmaceutical Biotechnology, Pasteur Institute, Tehran, Iran
4. School of Dentistry, Marquette University, Milwaukee, 53233, WI, United States

Source: Health Biotechnology and Biopharma Published:2021

Abstract

The present study is created to determine the effect of rs3783605 and its interaction with IL-17A, IL-17E and TNF-α cytokines on the action of VCAM-1 gene promoter in human umbilical vein endothelial cells (HUVEC). Recent research shows that IL-17A and TNF-α cytokines have main effect on VCAM-1 expression, and IL-17E as a proinflammatory ligand for IL-17 receptor homolog IL-17Rh1 might also partake in this process. Two vectors with altered rs3783605 alleles are fabricated to express the GFP. Unlike the other two cytokines, HUVECs stimulated with TNF-α alone show an increase of expression. The stimulation with IL-17A in addition to TNF-α show an increase of expression in G allele vector, while the stimulation with IL-17E in addition to TNF-α led to an increased expression in the cells containing an allele. The stimulation by IL-17A in addition to IL-17E led to decrease of expression in the cells containing G allele and stimulation with three cytokines simultaneously showed a decrease of expression in G allele vector. © 2020, Health Biotechnology and Biopharma.

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Amirreza Azimi (1)

Mohammad Vodjgani (1)

Style	Citing Format
MLA	Pakdel FD, et al.. "Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells." Health Biotechnology and Biopharma, vol. 4, no. 1, 2021, pp. 59-67.
APA	Pakdel FD, Pakdel JD, Tayebi L, Keramatipour M, Vodjgani M (2021). Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells. Health Biotechnology and Biopharma, 4(1), 59-67.
Chicago	Pakdel FD, Pakdel JD, Tayebi L, Keramatipour M, Vodjgani M. "Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells." Health Biotechnology and Biopharma 4, no. 1 (2021): 59-67.
Harvard	Pakdel FD et al. (2021) 'Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells', Health Biotechnology and Biopharma, 4(1), pp. 59-67.
Vancouver	Pakdel FD, Pakdel JD, Tayebi L, Keramatipour M, Vodjgani M. Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells. Health Biotechnology and Biopharma. 2021;4(1):59-67.
BibTex	@article{ author = {Pakdel FD and Pakdel JD and Tayebi L and Keramatipour M and Vodjgani M}, title = {Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells}, journal = {Health Biotechnology and Biopharma}, volume = {4}, number = {1}, pages = {59-67}, year = {2021} }
RIS	TY - JOUR AU - Pakdel FD AU - Pakdel JD AU - Tayebi L AU - Keramatipour M AU - Vodjgani M TI - Investigating Interaction Between Il-17A, Il-17E, Tnf-Α and Rs3783605 and Its Effect on Vcam-1 Promoter Activity in the Human Umbilical Vein Endothelial Cells JO - Health Biotechnology and Biopharma VL - 4 IS - 1 SP - 59 EP - 67 PY - 2021 ER -

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