A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders

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A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders Publisher Pubmed

Kamali AN¹ ; Noorbakhsh SM² ; Hamedifar H¹ ; Jadidiniaragh F^{3, 4} ; Yazdani R⁵ ; Bautista JM^{6, 7} ; Azizi G^{8, 9}

Source: Molecular Immunology Published:2019

Abstract

The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells co-express retinoic acid-related orphan receptor gamma t (RORγt) and transcription factor T-box-expressed-in-T-cells (T-bet) and produce both interleukin (IL)-17 and interferon (IFN)-γ. Recent reports have shown that Th1-like Th17 cells play crucial roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, as well as, some primary immunodeficiency with autoimmune features. Here, the actual mechanisms for Th17 cells plasticity to Th1-like Th17 cells are discussed and reviewed in association to the role that Th1-like Th17 cells have on inflammatory and autoimmune disorders. © 2018 Elsevier Ltd

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Style	Citing Format
MLA	Kamali AN, et al.. "A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders." Molecular Immunology, vol. 105, no. , 2019, pp. 107-115.
APA	Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidiniaragh F, Yazdani R, Bautista JM, Azizi G (2019). A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders. Molecular Immunology, 105(), 107-115.
Chicago	Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidiniaragh F, Yazdani R, Bautista JM, Azizi G. "A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders." Molecular Immunology 105, no. (2019): 107-115.
Harvard	Kamali AN et al. (2019) 'A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders', Molecular Immunology, 105(), pp. 107-115.
Vancouver	Kamali AN, Noorbakhsh SM, Hamedifar H, Jadidiniaragh F, Yazdani R, Bautista JM, et al.. A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders. Molecular Immunology. 2019;105():107-115.
BibTex	@article{ author = {Kamali AN and Noorbakhsh SM and Hamedifar H and Jadidiniaragh F and Yazdani R and Bautista JM and Azizi G}, title = {A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders}, journal = {Molecular Immunology}, volume = {105}, number = {}, pages = {107-115}, year = {2019} }
RIS	TY - JOUR AU - Kamali AN AU - Noorbakhsh SM AU - Hamedifar H AU - Jadidiniaragh F AU - Yazdani R AU - Bautista JM AU - Azizi G TI - A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders JO - Molecular Immunology VL - 105 IS - SP - 107 EP - 115 PY - 2019 ER -

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