Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Role for Th1-Like Th17 Cells in the Pathogenesis of Inflammatory and Autoimmune Disorders Publisher Pubmed



Kamali AN1 ; Noorbakhsh SM2 ; Hamedifar H1 ; Jadidiniaragh F3, 4 ; Yazdani R5 ; Bautista JM6, 7 ; Azizi G8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Faculty of Veterinary Sciences, Madrid, 28040, Spain
  7. 7. Research Institute Hospital 12 de Octubre, Madrid, 28041, Spain
  8. 8. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  9. 9. Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Molecular Immunology Published:2019


Abstract

The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells co-express retinoic acid-related orphan receptor gamma t (RORγt) and transcription factor T-box-expressed-in-T-cells (T-bet) and produce both interleukin (IL)-17 and interferon (IFN)-γ. Recent reports have shown that Th1-like Th17 cells play crucial roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, as well as, some primary immunodeficiency with autoimmune features. Here, the actual mechanisms for Th17 cells plasticity to Th1-like Th17 cells are discussed and reviewed in association to the role that Th1-like Th17 cells have on inflammatory and autoimmune disorders. © 2018 Elsevier Ltd
Related Docs
View other Related Docs
1. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
2. The Newly Identified T Helper 22 Cells Lodge in Leukemia, International Journal of Hematology-Oncology and Stem Cell Research (2015)
3. The Imbalance of Circulating T Helper Subsets and Regulatory T Cells in Patients With Lrba Deficiency: Correlation With Disease Severity, Journal of Cellular Physiology (2018)
4. The Profile of Il-4, Il-5, Il-10 and Gata3 in Patients With Lrba Deficiency and Cvid With No Known Monogenic Disease: Association With Disease Severity, Allergologia et Immunopathologia (2019)
5. A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment, Clinical Medicine and Research (2023)
6. The Roles of Cd4+ T-Cells in Tumor Immunity, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
7. Features and Roles of T Helper 22 Cells in Immunological Diseases and Malignancies, Scandinavian Journal of Immunology (2021)
8. Circulating Helper T-Cell Subsets and Regulatory T Cells in Patients With Common Variable Immunodeficiency Without Known Monogenic Disease, Journal of Investigational Allergology and Clinical Immunology (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (7)
Laleh Sharifi (2)
Other Related Docs
9. Features and Roles of T Helper 9 Cells and Interleukin 9 in Immunological Diseases, Allergologia et Immunopathologia (2019)
10. Evaluation of Expression of Lrba and Ctla-4 Proteins in Common Variable Immunodeficiency Patients, Immunological Investigations (2022)
11. Emerging Therapeutic Potential of Regulatory T (Treg) Cells for Rheumatoid Arthritis: New Insights and Challenges, International Immunopharmacology (2022)
12. The Effects of Stimulation With Pma/Ionomycin on Cd4+ T Cell Proliferation and Surface Cd4 Molecule Modulation of Patients With Lrba Deficiency and Cvid With the Unsolved Genetic Defect, Endocrine# Metabolic and Immune Disorders - Drug Targets (2022)
13. The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia, Future Oncology (2015)
14. Clinical, Immunologic, and Molecular Spectrum of Patients With Lps-Responsive Beige-Like Anchor Protein Deficiency: A Systematic Review, Journal of Allergy and Clinical Immunology: In Practice (2019)
15. Effect of Guluronic Acid (G2013), As a New Anti-Inflammatory Drug on Gene Expression of Pro-Inflammatory and Anti-Inflammatory Cytokines and Their Transcription Factors in Rheumatoid Arthritis Patients, Iranian Journal of Allergy# Asthma and Immunology (2019)
16. Identifying Novel Mutations in Iranian Patients With Lps-Responsive Beige-Like Anchor Protein (Lrba) Deficiency, Immunological Investigations (2021)
17. Synergistic Therapeutic Effect of Mesenchymal Stem Cells and Tolerogenic Dendritic Cells in an Acute Colitis Mouse Model, International Immunopharmacology (2020)
18. Influence of Β-D-Mannuronic Acid, As a New Member of Non-Steroidal An-Ti-Inflammatory Drugs Family, on the Expression Pattern of Chemokines and Their Receptors in Rheumatoid Arthritis, Current Drug Discovery Technologies (2021)
19. Ctla-4 Expression in Cd4 + T Cells From Patients With Lrba Deficiency and Common Variable Immunodeficiency With No Known Monogenic Disease, Journal of Investigational Allergology and Clinical Immunology (2018)
20. The Rationale for Selenium Supplementation in Inflammatory Bowel Disease: A Mechanism-Based Point of View, Nutrition (2021)
21. Dry Eye Disease: Emerging Approaches to Disease Analysis and Therapy, Journal of Clinical Medicine (2019)
22. The Paradox of Th17 Cell Functions in Tumor Immunity, Cellular Immunology (2017)
23. High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy, NeuroImmunoModulation (2018)
24. Il-21 and Il-21 Receptor in the Immunopathogenesis of Multiple Sclerosis, Journal of Immunotoxicology (2016)
25. Inborn Errors of Immunity Reveal Molecular Requirements for Generation and Maintenance of Human Cd4+ Il-9–Expressing Cells, Journal of Allergy and Clinical Immunology (2025)
26. Immunomodulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis Mice, a Multiple Sclerosis Animal Model, Iranian Journal of Allergy# Asthma and Immunology (2023)
27. Characterization of Cd4+ and Cd8+ T Cell Subsets and Interferon Regulatory Factor 4 (Irf4) in Ms Patients Treated With Fingolimod (Fty-720); a Follow-Up Study, Iranian Journal of Allergy# Asthma and Immunology (2018)
28. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
29. Th17/Treg Immunoregulation and Implications in Treatment of Sulfur Mustard Gas-Induced Lung Diseases, Expert Review of Clinical Immunology (2017)
30. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency, Allergy# Asthma and Clinical Immunology (2023)
31. Th1-Th17 Ratio As a New Insight in Rheumatoid Arthritis Disease, Iranian Journal of Allergy# Asthma and Immunology (2018)
32. Rheumatologic Complications in a Cohort of 227 Patients With Common Variable Immunodeficiency, Scandinavian Journal of Immunology (2018)
33. Regulatory T Cells in Breast Cancer As a Potent Anti-Cancer Therapeutic Target, International Immunopharmacology (2020)
34. Autoimmune Diseases, Clinical Immunology (2022)
35. Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria, Science Immunology (2023)
36. Th9 Cells As a New Player in Inflammatory Skin Disorders, Iranian Journal of Allergy# Asthma and Immunology (2019)
37. Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases, Iranian Journal of Allergy# Asthma and Immunology (2015)
38. Leishmaniasis and Autoimmunity in Patient With Lps-Responsive Beige-Like Anchor Protein (Lrba) Deficiency, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
39. Autoimmune Manifestations Among 461 Patients With Monogenic Inborn Errors of Immunity, Pediatric Allergy and Immunology (2021)
40. G2-Lymphocyte Chromosomal Radiosensitivity in Patients With Lps Responsive Beige-Like Anchor Protein (Lrba) Deficiency, International Journal of Radiation Biology (2019)
41. The Immunomodulatory Effects of All-Trans Retinoic Acid and Docosahexaenoic Acid Combination Treatment on the Expression of Il-2, Il-4, T-Bet, and Gata3 Genes in Pbmcs of Multiple Sclerosis Patients, Neurological Research (2023)