Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa

Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa Publisher Pubmed

Vafaei SY¹ ; Esmaeili M² ; Amini M³ ; Atyabi F^{1, 2} ; Ostad SN⁴ ; Dinarvand R^{1, 2}

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1. Nanomedicine and Biomaterial Lab., Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, 16 Azar St, Enqelab Sq, Tehran, 1417614411, Iran
2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, 16 AzarSt, Enqelab Sq, Tehran, 1417614411, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, 16 Azar St, Enqelab Sq, Tehran, 1417614411, Iran
4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, 16 AzarSt, Enqelab Sq, Tehran, 1417614411, Iran

Source: Carbohydrate Polymers Published:2016

Abstract

To develop a nanoparticulate drug carrier for targeting of the inflamed intestinal mucosa, amphiphilic hyaluronic acid (HA) conjugates were synthesized, which could form self-assembled nanoparticles (NPs) in aqueous solution and budesonide (BDS) was loaded into the HANPs. Their particle sizes were in the range of 177 to 293 nm with negative surface charge. The model of inflammatory CACO-2 cells was utilized to investigate the therapeutic potential of budesonide loaded HA nanocarriers. The highest expression of CD44 receptors was found on inflamed Caco-2 cells, as determined by flow cytometry. FITC-labeled HANPs revealed greater uptake in inflamed CACO-2 cells compared to untreated CACO-2 and CD44-negative cell lines, NIH3T3. BDS loaded HANPs displayed almost no toxicity indicating HANPs are excellent biocompatible nano-carriers. BDS loaded HANPs demonstrated higher anti-inflammatory effect on IL-8 and TNF-α secretion in inflamed cell model compared to the same dose of free drug. These results revealed the promising potential of HA nanoparticles as a targeted drug delivery system for IBD treatment. © 2016 Elsevier Ltd. All rights reserved.

2. A Systematic Review of Nano Formulation of Natural Products for the Treatment of Inflammatory Bowel Disease: Drug Delivery and Pharmacological Targets, DARU# Journal of Pharmaceutical Sciences (2018)

3. Targeting Pathophysiological Changes Using Biomaterials-Based Drug Delivery Systems: A Key to Managing Inflammatory Bowel Disease, Frontiers in Pharmacology (2022)

4. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)

5. Novel Polyurethane-Based Ionene Nanoparticles Electrostatically Stabilized With Hyaluronic Acid for Effective Gene Therapy, Colloids and Surfaces B: Biointerfaces (2024)

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Mohammad Abdollahi (2)

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Style	Citing Format
MLA	Vafaei SY, et al.. "Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa." Carbohydrate Polymers, vol. 144, no. , 2016, pp. 371-381.
APA	Vafaei SY, Esmaeili M, Amini M, Atyabi F, Ostad SN, Dinarvand R (2016). Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa. Carbohydrate Polymers, 144(), 371-381.
Chicago	Vafaei SY, Esmaeili M, Amini M, Atyabi F, Ostad SN, Dinarvand R. "Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa." Carbohydrate Polymers 144, no. (2016): 371-381.
Harvard	Vafaei SY et al. (2016) 'Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa', Carbohydrate Polymers, 144(), pp. 371-381.
Vancouver	Vafaei SY, Esmaeili M, Amini M, Atyabi F, Ostad SN, Dinarvand R. Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa. Carbohydrate Polymers. 2016;144():371-381.
BibTex	@article{ author = {Vafaei SY and Esmaeili M and Amini M and Atyabi F and Ostad SN and Dinarvand R}, title = {Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa}, journal = {Carbohydrate Polymers}, volume = {144}, number = {}, pages = {371-381}, year = {2016} }
RIS	TY - JOUR AU - Vafaei SY AU - Esmaeili M AU - Amini M AU - Atyabi F AU - Ostad SN AU - Dinarvand R TI - Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa JO - Carbohydrate Polymers VL - 144 IS - SP - 371 EP - 381 PY - 2016 ER -

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