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A Systematic Review of Nano Formulation of Natural Products for the Treatment of Inflammatory Bowel Disease: Drug Delivery and Pharmacological Targets Publisher Pubmed



Taghipour YD1, 2, 3 ; Bahramsoltani R2, 4 ; Marques AM5 ; Naseri R6 ; Rahimi R4 ; Haratipour P7, 8 ; Iranpanah A9 ; Farzaei MH10, 11 ; Abdollahi M12, 13
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Oswaldo Cruz Foundation (FIOCRUZ), Institute of Technology in Pharmaceuticals (Farmanguinhos), Rio de Janeiro, RJ, Brazil
  6. 6. Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  8. 8. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Los Angeles, CA, United States
  9. 9. Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  11. 11. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  12. 12. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: DARU# Journal of Pharmaceutical Sciences Published:2018


Abstract

Inflammatory bowel diseases (IBD), which is classified into Crohn’s disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article. This approach may potentially overcome some complications that are associated with conventional means of colon drug delivery. Meanwhile, in vitro and in vivo studies pave the way for understanding of the mechanism that lies behind this chronic relapsing disease and potentially more effective treatment. [Figure not available: see fulltext.]. © 2018, Springer Nature Switzerland AG.
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