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The Relationship Between Gad65 Autoantibody and the Risk of T1dm Onset Publisher



Keshavarzi E1 ; Noveiry BB2, 3 ; Rezaei N4, 5, 6
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Immunology Project (CIP), Universal Scientific Education of Research Network (USERN), Waterbury, CT, United States
  3. 3. Department of Medicine, Saint Mary’s Hospital, Waterbury, CT, United States
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

Source: Journal of Diabetes and Metabolic Disorders Published:2022


Abstract

Objectives: Type 1 diabetes mellitus (T1DM) is a well-known autoimmune disease, characterized by β-cell destruction in pancreas islet cells, which results insulin deficiency and subsequent hyperglycemic sequelae. While there is screening for type 2 DM that leads to better glycemic control and outcome, the majority of T1DM patients are diagnosed when much of the pancreatic cells and their function are disturbed. The aim of this article is to present an overview of the effective factors in the positivity of Glutamic acid decarboxylase antibody)GADA(and identifying the high-risk individuals for T1DM. Methods: We searched English literature available at National Library of Medicine via PubMed, and Google Scholar through December 2020. Finally, 79 papers have been included in the study. Studies were summarized based on the number of positive autoantibodies and onset of T1DM over time and GADA correlation with different variables. Conclusions: GADA is an easy marker to measure that can be detected many months prior to the clinical presentation and remains positive even after early childhood. © 2022, The Author(s), under exclusive licence to Tehran University of Medical Sciences.