Application of Mesenchymal Stem Cells and Exosome Alone or Combination Therapy As a Treatment Strategy for Wound Healing Publisher Pubmed



Nouri S¹ ; Shokraneh S² ; Fatehi Shalamzari P³ ; Ahmed MH⁴ ; Radi UK⁵ ; Idan AH⁶ ; Ebrahimi MJ⁷ ; Moafi M⁷ ; Gholizadeh N⁸ Show Affiliations
Source: Cell Biochemistry and Biophysics Published:2024

Abstract

The process of wound healing consists of multiple phases, and any disruptions in these phases can lead to the wound becoming chronic and impose heavy financial and psychological costs on the patient and a huge economic burden on the country’s healthcare system. Various treatments such as drugs, matrix and scaffolds, blood products, cell therapy, and a combination of these treatments are used for wound healing. The use of mesenchymal stem cells (MSCs) is one of these methods that have produced appropriate responses in the healing of patients’ wounds. MSCs by secreting growth factors, cytokines, chemokines, and RNAs elicit changes in cell proliferation, migration, growth, signaling, immunomodulation, and wound re-epithelialization process, and as a result, accelerate wound closure and wound healing. These cells can be isolated from different body sources with different cell characteristics and used directly on the wound site or by injection. In addition, MSCs-derived exosomes have attracted growing attention due to circumventing concerns relating to the direct use of MSCs. To increase the performance of MSCs, they can be used together with other compounds such as platelets, matrices, or scaffolds. This study examined the functions of MSCs in wound healing, as well as the vesicles they secrete, cellular and molecular mechanisms, and combined treatments with MSCs for wound healing. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.