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Transplantation of Adipose Derived Stem Cells in Diabetes Mellitus; Limitations and Achievements Publisher



Tajali R4 ; Eidi A4 ; Tafti HA5 ; Pazouki A6 ; Kamarul T3 ; Sharifi AM1, 2, 3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Stem cell and regenerative Medicine research center, Iran University of medical Sciences, Tehran, Iran
  3. 3. Tissue Engineering Group, (NOCERAL), Department of Orthopedics Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  4. 4. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Minimally Invasive Surgery research center, IRAN University of Medical Sciences Tehran, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2023


Abstract

Objectives: Diabetes mellitus (DM) is a complex metabolic disease that results from impaired insulin secreting pancreatic β-cells or insulin resistance. Although available medications help control the disease, patients suffer from its complications. Therefore, finding effective therapeutic approaches to treat DM is a priority. Adipose Derived Stem Cells (ADSCs) based therapy is a promising strategy in various regenerative medicine applications, but its systematic translational use is still somewhat out of reach. This review is aimed at clarifying achievements as well as challenges facing the application of ADSCs for the treatment of DM, with a special focus on the mechanisms involved. Methods: Literature searches were carried out on “Scopus”, “PubMed” and “Google Scholar” up to September 2022 to find relevant articles in the English language for the scope of this review. Results: Recent evidence showed a significant role of ADSC therapies in DM by ameliorating insulin resistance and hyperglycemia, regulating hepatic glucose metabolism, promoting β cell function and regeneration, and functioning as a gene delivery tool. In addition, ADSCs could improve diabetic wound healing by promoting collagen deposition, inhibiting inflammation, and enhancing angiogenesis. Conclusion: Overall, this literature review revealed the great clinical implications of ADSCs for translating into the clinical setting for the treatment of diabetes. However, further large-scale and controlled studies are needed to overcome challenges and confirm the safety and optimal therapeutic scheme before daily clinical application. © 2023, The Author(s), under exclusive licence to Tehran University of Medical Sciences.
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