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Global Epidemiology of Hbv Infection Among Hemodialysis Patients: A Systematic Review and Meta-Analysis Publisher Pubmed



Khalesi Z1 ; Razizadeh MH2 ; Javadi M3 ; Bahavar A4 ; Keyvanlou Z5 ; Saadati H6 ; Letafati A1 ; Khatami A2 ; Kachooei A2 ; Khales P7 ; Alborzi E2 ; Hosseini M2 ; Tambrchi V4 ; Jafari Maskouni E8 Show All Authors
Authors
  1. Khalesi Z1
  2. Razizadeh MH2
  3. Javadi M3
  4. Bahavar A4
  5. Keyvanlou Z5
  6. Saadati H6
  7. Letafati A1
  8. Khatami A2
  9. Kachooei A2
  10. Khales P7
  11. Alborzi E2
  12. Hosseini M2
  13. Tambrchi V4
  14. Jafari Maskouni E8
  15. Taheri N8
  16. Zafarani A9
  17. Motlaghzadeh S2
  18. Dehghani H10
  19. Shalpoush N11
  20. Masoudi A12
  21. Noorafaz M13
  22. Habib Z2
  23. Zarei M14, 15
  24. Kiani SJ2
  25. Ghorbani S2
Show Affiliations
Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Department of Virology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  7. 7. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  9. 9. Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Biology, Jahrom Branch, Islamic Azad University, Fars, Iran
  11. 11. Biology Cellular and Molecular Microbiology, Islamic Azad University of Medical Sciences, Tehran, Iran
  12. 12. Department of Laboratory Sciences, Faculty of Allied Medical Sciences, Medical University of Qom, Qom, Iran
  13. 13. Department of Microbiology, Faculty of Basic Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran
  14. 14. Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
  15. 15. John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, United States

Source: Microbial Pathogenesis Published:2023


Abstract

Background & aims: Hemodialysis (HD) is a life-saving procedure that purifies the blood in patients with end-stage renal disease (ESRD). Among all major complications, blood-borne diseases like hepatitis B virus (HBV) may be exposed as serious side effects of hemodialysis. A comprehensive review of the global burden of HBV among HD patients has not been written so far. The aim of the current systematic review and meta-analysis was to determine the globally epidemiology of HBV infection among HD patients. Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, articles that investigated the prevalence of HBV among HD patients were searched from the major databases such as EMBASE, PubMed, Web of Science collection, and Scopus. Pooled prevalence with 95% CI and identification of heterogeneity were obtained using the random effects model and Cochran's Q-test, respectively, and quantification was evaluated using the I2 statistics. All statistical analyses were performed by STATA 14.1 statistical software. Results: among 322 datasets (795,623 cases) that included in this study, the pooled prevalence of HBV infection among HD patients was 7.32% (95% CI: 6.53–8.15%; I2 = 97.91%), including 7.57% (95% CI: 6.69–8.48%) for HBsAg and 6.09% (95% CI: 4.05–8.49%) for DNA, respectively. In addition, based on geographic area, the prevalence was 7.44% (95% CI: 6.35–8.61%) in Asia, 4.32% (95% CI: 2.21–7.04%) in North America, 7.07% (95% CI: 6.35–8.61%) in Europe, 5.52% (95% CI: 3.60–7.78%) in Africa, 8.45% (95% CI: 5.81–11.78%) in Oceania, and 9.73% (95% CI: 7.11–12.70%) in South America. Conclusions: Our analysis indicates a relatively high prevalence of HBV infection in HD patients, even in some developed countries. Considering that ESRD patients are not able to properly respond to the vaccination strategies in order to develop an acceptable immunity, vaccination of healthy individuals is highly recommended to arm their bodies for possible immunocompromise conditions in the future. Moreover, donated blood in blood transfusion centers should be checked for possible hepatitis B virus infection using sensitive molecular tests. © 2023
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1. Hepatitis B Virus Infection in Iranian Hemodialysis Patients: A Systematic Review and Meta-Analysis, Iranian Journal of Kidney Diseases (2018)