Pdcd1 Single Nucleotide Genes Polymorphisms Confer Susceptibility to Juvenile-Onset Systemic Lupus Erythematosus Publisher Pubmed



Mahmoudi M¹ ; Rezaiemanesh A^{1, 2} ; Salmaninejad A^{1, 3} ; Harsini S⁴ ; Poursani S¹ ; Bahrami T^{1, 3} ; Tahghighi F⁵ ; Ziaee V⁵ ; Rezaei N^{2, 4, 6, 7} Show Affiliations
Source: Autoimmunity Published:2015

Abstract

Juvenile-onset systemic lupus erythematosus (JSLE) is a multisystem autoimmune disease in which both the genetic and environmental factors seem to be involved in the etiopathogenesis of the disease. The aim of this study was to evaluate the association of programmed cell death 1 (PDCD1, also called PD-1) gene polymorphisms with JSLE susceptibility in Iranian population. In this case-control association study, three PDCD1 SNPs, including PD-1.1 G/A, PD-1.3 G/A and PD-1.9 C/T were genotyped in 50 Iranian patients with JSLE and 202 healthy unrelated controls, using PCR-RFLP method. The PD-1.1 A allele was found to be more frequent in the case group compared with controls (6% vs. 1.5%, p = 0.024). Moreover, the GG genotype was less frequent in cases than in controls (88% vs. 97%, p = 0.021). The other PDCD1 SNPs did not show association. At the haplotypic level, no significant differences was recognized between the two groups of case and control neither for the GAC (PD-1.1 G, PD-1.3 A, PD-1.9 C) nor for the GGC haplotype (PD-1.1 G, PD-1.3 G, PD-1.9 C). Our findings support the influence of the PD1.1 A SNP on the development of JSLE in Iranian population. © 2015 Informa UK Ltd.