Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property

Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property Publisher

Fatahi Y^{1, 2, 3} ; Sanjabi M⁴ ; Rakhshani A¹ ; Motasadizadeh H¹ ; Darbasizadeh B⁴ ; Bahadorikhalili S⁵ ; Farhadnejad H⁴

Show Affiliations

1. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Universal Scientific Education and Research Network (USERN), Tehran, Iran
4. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2021

Abstract

The main aim of the present study was to fabricate levofloxacin (LEV)-loaded halloysite nanotube (HNT)/sodium alginate (SA)-poly (ethylene oxide) (PEO) nanocomposite fibrous mats and evaluate their drug release and antibacterial activity. LEV was incorporated into the lumen of HA nanotubes via cyclic vacuum pumping in/out process. Structure and morphology of HNT-LEV nanohybrid particles and HNT-LEV/SA-PEO nanocomposite fibers were characterized via X-ray diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA), and fourier transform infrared (FT-IR) techniques. SEM images indicated that the addition of HNT-LEV nanohybrid particles and LEV into the fabricated nanofibers resulted in changing their average diameter. In-vitro release profile showed that LEV release from HNT-LEV/SA-PEO nanocomposite fibers slowly occurred. Their anti-bacterial activity was studied against S. aureus and E. coli and found that HNT-LEV/SA-PEO nanocomposite fibers show suitable antimicrobial activity. Sustained drug release profile and suitable anti-bacterial activity of HNT-LEV/SA-PEO nanocomposite fibers indicated that it was a good biomaterial for wound dressings. © 2021 Elsevier B.V.

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Mohammad Akrami (1)

Rassoul Dinarvand (1)

Style	Citing Format
MLA	Fatahi Y, et al.. "Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property." Journal of Drug Delivery Science and Technology, vol. 64, no. , 2021, pp. -.
APA	Fatahi Y, Sanjabi M, Rakhshani A, Motasadizadeh H, Darbasizadeh B, Bahadorikhalili S, Farhadnejad H (2021). Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property. Journal of Drug Delivery Science and Technology, 64(), -.
Chicago	Fatahi Y, Sanjabi M, Rakhshani A, Motasadizadeh H, Darbasizadeh B, Bahadorikhalili S, Farhadnejad H. "Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property." Journal of Drug Delivery Science and Technology 64, no. (2021): -.
Harvard	Fatahi Y et al. (2021) 'Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property', Journal of Drug Delivery Science and Technology, 64(), pp. -.
Vancouver	Fatahi Y, Sanjabi M, Rakhshani A, Motasadizadeh H, Darbasizadeh B, Bahadorikhalili S, et al.. Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property. Journal of Drug Delivery Science and Technology. 2021;64():-.
BibTex	@article{ author = {Fatahi Y and Sanjabi M and Rakhshani A and Motasadizadeh H and Darbasizadeh B and Bahadorikhalili S and Farhadnejad H}, title = {Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property}, journal = {Journal of Drug Delivery Science and Technology}, volume = {64}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Fatahi Y AU - Sanjabi M AU - Rakhshani A AU - Motasadizadeh H AU - Darbasizadeh B AU - Bahadorikhalili S AU - Farhadnejad H TI - Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property JO - Journal of Drug Delivery Science and Technology VL - 64 IS - SP - EP - PY - 2021 ER -

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