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Dual Drug Delivery System Based on Ph-Sensitive Silk Fibroin/Alginate Nanoparticles Entrapped in Pnipam Hydrogel for Treating Severe Infected Burn Wound Publisher Pubmed



Rezaei F1 ; Damoogh S2 ; Reis RL3 ; Kundu SC3 ; Mottaghitalab F4 ; Farokhi M2
Authors
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Authors Affiliations
  1. 1. Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, 15875/4413, Iran
  2. 2. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  3. 3. 3Bs Research Group, I3Bs - Research Institute on Biomaterials, Biodegradable and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Avepark, Barco, Guimaraes, 4805-017, Portugal
  4. 4. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Biofabrication Published:2020


Abstract

Herein, the pH-sensitive vancomycin (VANCO) loaded silk fibroin-sodium alginate nanoparticles (NPs) embedded in poly(N-isopropylacrylamide) (PNIPAM) hydrogel containing epidermal growth factor (EGF) are introduced for treating chronic burn wound infections. The hybrid system was developed to control the release rates of an antibiotic and growth factor for optimal treatment of burn infections. VANCO had a pH responsive release behavior from the nanoparticle (NP) and showed higher release rate in an alkaline pH compared to the neutral pH during 10 d. About 30% of EGF was also released from the hydrogel within 20 d. The released VANCO and EGF preserved their bioactivity more than ∼ 80%. The suitable physico-chemical properties and cellular behaviors of PNIPAM hydrogel supported the proliferation and growth of the fibroblast cells. Furthermore, the higher re-epithelialization with good wound contraction rate, neovascular formation, and expression of transforming growth factor-beta were observed in S. aureus infected rat burn wound by using the hydrogel containing VANCO and EGF compared with untreated wounds and hydrogel alone. The wound infection was also significantly reduced in the groups treated with the hydrogels containing VANCO. Overall, in vitro and in vivo results suggested that developed hybrid system would be a promising construct to treat severe wound infection. © 2020 IOP Publishing Ltd.
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