Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis

Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis Publisher Pubmed

Mansour A¹ ; Aboeerad M¹ ; Qorbani M^{2, 3} ; Hashemi Taheri AP⁴ ; Pajouhi M¹ ; Keshtkar AA⁵ ; Larijani B¹ ; Mohajeritehrani MR¹ ; Ganji MR⁶

Show Affiliations

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
3. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Radiology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Health Science Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6. Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Nephrology Published:2018

Abstract

Background: Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This study aimed to evaluate the relation between serum OPG, RANKL concentration, and bone mineral density (BMD) in patients with kidney stone disease. Methods: Forty-four nephrolithiasis patients with either low bone mass or normal BMD (considered control group) were enrolled in this study. BMD was measured at lumbar spine (L1-L4) and femoral neck by dual-energy X-ray absorptiometry (DEXA). The serum OPG and RANKL were determined using the ELISA method. Results: The median levels of serum OPG were significantly higher in nephrolithiasis patients with low bone mass compared to the nephrolithiasis patients with normal BMD (3.9 pmol/l versus 3.1 pmol/l; P = 0.03), respectively. Negative correlation was detected between bone densities of femoral neck and OPG in patients with nephrolithiasis (r = -.0344, P = 0.02). Conclusion: The present study showed that high serum fasting OPG levels may be indicative of femoral neck BMD in patients with nephrolithiasis. © 2018 The Author(s).

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Style	Citing Format
MLA	Mansour A, et al.. "Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis." BMC Nephrology, vol. 19, no. 1, 2018, pp. -.
APA	Mansour A, Aboeerad M, Qorbani M, Hashemi Taheri AP, Pajouhi M, Keshtkar AA, Larijani B, Mohajeritehrani MR, Ganji MR (2018). Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis. BMC Nephrology, 19(1), -.
Chicago	Mansour A, Aboeerad M, Qorbani M, Hashemi Taheri AP, Pajouhi M, Keshtkar AA, Larijani B, Mohajeritehrani MR, Ganji MR. "Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis." BMC Nephrology 19, no. 1 (2018): -.
Harvard	Mansour A et al. (2018) 'Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis', BMC Nephrology, 19(1), pp. -.
Vancouver	Mansour A, Aboeerad M, Qorbani M, Hashemi Taheri AP, Pajouhi M, Keshtkar AA, et al.. Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis. BMC Nephrology. 2018;19(1):-.
BibTex	@article{ author = {Mansour A and Aboeerad M and Qorbani M and Hashemi Taheri AP and Pajouhi M and Keshtkar AA and Larijani B and Mohajeritehrani MR and Ganji MR}, title = {Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis}, journal = {BMC Nephrology}, volume = {19}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Mansour A AU - Aboeerad M AU - Qorbani M AU - Hashemi Taheri AP AU - Pajouhi M AU - Keshtkar AA AU - Larijani B AU - Mohajeritehrani MR AU - Ganji MR TI - Association Between Low Bone Mass and the Serum Rankl and Opg in Patients With Nephrolithiasis JO - BMC Nephrology VL - 19 IS - 1 SP - EP - PY - 2018 ER -

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