Status of Circulating Bone Turnover Markers in Elderly Osteoporosis/Osteopenia Patients in Comparison With Healthy Subjects Publisher



Tehrani SS^{1, 2} ; Moallem M³ ; Ebrahimi R^{1, 2} ; Hosseini SR³ ; Nooreddini H⁴ ; Parsian H³ Show Affiliations
Source: Asian Biomedicine Published:2020

Abstract

Background: In the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects. Objective: To investigate the serum levels of bone turnover markers in elderly osteoporosis patients. Methods: The serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal-Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS. Results: Levels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (P = 0.003 and 0.009, respectively). Furthermore, PINP and B-ALP levels had the best area under the curve, sensitivity, and specificity for the discrimination between patients with osteoporosis and healthy individuals. Conclusion: In conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool. © 2020 Tehrani et al., published by Sciendo.