Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach

Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach Publisher

Vakili H¹ ; Mohseni M¹ ; Makki H¹ ; Yahyaei H¹ ; Ghanbari H^{2, 3} ; Gonzalez A⁴ ; Irusta L⁴

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1. Amirkabir University of Technology, Department of Polymer and Color Engineering, 424 Hafez Ave., Tehran, Iran
2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Italia Street, Tehran, Iran
3. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences (TUMS), Italia Street, Tehran, Iran
4. POLYMAT, Department of Polymer Science and Technology, University of the Basque Country (UPV/EHU), Avda. Tolossa 72, Donostia-San Sebastian 20018, Spain

Source: Progress in Organic Coatings Published:2021

Abstract

Incorporation of hydrophilic and hydrophobic agents into a polymer backbone is an effective approach to control its interfacial characteristics. Segmented polyurethanes (PUs) are easy-fabricating and cost-effective candidates in this respect. In this work, we have synthesized polycarbonate (PC)-based PUs containing hydrophilic Polyethylene glycol (PEG) and hydrophobic Polyhedral Oligomeric Silsesquioxane (POSS) in the lab as well as in molecular dynamics simulations. We employed several experimental techniques and a coarse-grained (CG) molecular dynamics (MD) method to evaluate the morphology and microphase arrangement of PUs. We successfully synthesized superior hydrophilic and hydrophobic coatings by replacing some parts of the soft segment (PC) with PEG and the chain extender (1,4-butandiol) with POSS, respectively. Our CG MD simulations showed that POSS is dispersed in PC uniformly, while PEG is completely phase separated from PC and formed a lamellar structure. This was also confirmed by experimental thermal analysis. Eventually, water contact angle (WCA) measurements proved development of very hydrophilic (PU-PEG), slightly hydrophilic (PU), and very hydrophobic (PU-POSS) coatings. The surface free energy analysis indicated that POSS decreases polar and apolar components of surface free energy, while PU-PEG exhibits omniphilic behavior. The presence of PEG and POSS on the surface was also confirmed by contact angle and AFM measurements. According to MTT and LDH assays, PEG and POSS incorporation significantly enhanced the biocompatibility of PU such that PU-PEG and PU-POSS coatings become prospective candidates for biomedical applications. © 2020 Elsevier B.V.

2. Microphase Arrangement of Smart Superhydrophilic Segmented Polyurethanes at Their Interface With Water, Langmuir (2020)

3. Synthesis and Characterization of Polyhedral Oligomeric Titanized Silsesquioxane: A New Biocompatible Cage Like Molecule for Biomedical Application, Materials Science and Engineering C (2016)

Experts (# of related papers)

Hossein Ghanbari (3)

Style	Citing Format
MLA	Vakili H, et al.. "Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach." Progress in Organic Coatings, vol. 150, no. , 2021, pp. -.
APA	Vakili H, Mohseni M, Makki H, Yahyaei H, Ghanbari H, Gonzalez A, Irusta L (2021). Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach. Progress in Organic Coatings, 150(), -.
Chicago	Vakili H, Mohseni M, Makki H, Yahyaei H, Ghanbari H, Gonzalez A, Irusta L. "Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach." Progress in Organic Coatings 150, no. (2021): -.
Harvard	Vakili H et al. (2021) 'Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach', Progress in Organic Coatings, 150(), pp. -.
Vancouver	Vakili H, Mohseni M, Makki H, Yahyaei H, Ghanbari H, Gonzalez A, et al.. Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach. Progress in Organic Coatings. 2021;150():-.
BibTex	@article{ author = {Vakili H and Mohseni M and Makki H and Yahyaei H and Ghanbari H and Gonzalez A and Irusta L}, title = {Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach}, journal = {Progress in Organic Coatings}, volume = {150}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Vakili H AU - Mohseni M AU - Makki H AU - Yahyaei H AU - Ghanbari H AU - Gonzalez A AU - Irusta L TI - Synthesis of Segmented Polyurethanes Containing Different Oligo Segments: Experimental and Computational Approach JO - Progress in Organic Coatings VL - 150 IS - SP - EP - PY - 2021 ER -

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Abstract