Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies

Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies Publisher Pubmed

Kalantari E^{1, 3} ; Naghib SM¹ ; Iravani NJ² ; Esmaeili R² ; Naimijamal MR³ ; Mozafari M⁴

Show Affiliations

1. Nanobiotechnology Engineering Division, Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran
2. Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
3. Research Laboratory of Green Organic Synthesis and Polymers, Chemistry Department, Iran University of Science and Technology (IUST), Tehran, Iran
4. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Materials Science and Engineering C Published:2019

Abstract

In this study, a simple and facile strategy was developed for the synthesis of novel hydroxyapatite (HA)/nanostructured monticellite ceramic composites by mechanical method. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive x-ray spectroscopy (EDS) were used to peruse the phase structure, and morphology of soaked ceramic composites in simulated body fluid (SBF). The in vitro bioactivity of HA-based ceramic composites with nanostructured monticellite ranging from 0 to 50 wt% was evaluated via investigating the formation ability of bone-like calcium phosphates in SBF and the effect of obtained extracts from composites dissolution on osteoblast-like G-292 cell line. Moreover, In vitro cytocompatibility of the HA/monticellite ceramic composites was investigated by MTT, cell growth & adhesion and alkaline phosphatase (ALP) activity assays, and quantitative real-time PCR analysis. The results showed that HA/nanostructured monticellite ceramic composites could induce apatite formation in SBF. The cell proliferation and growth exposed to ceramic composites extracts were significantly stimulated and promoted at a certain concentration range compared to control for various time periods of cell culture. The optimized composite extract enhanced considerably gene expression of G-292 type X collagen (COLX) at different days. Also, G-292 cells were spread and adhered well on the ceramic composite disc. Furthermore, ALP activity of G-292 cells exposed to ceramic composites extracts was dramatically enhanced in comparison with pure HA extract (as control) at different concentrations for various time periods of cell culture. The results suggest that the optimized HA/nanostructured monticellite composite is promising biomaterial for clinical applications such as orthopedic and dentistry. © 2019 Elsevier B.V.

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Experts (# of related papers)

Mahmoud Azami (1)

Style	Citing Format
MLA	Kalantari E, et al.. "Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies." Materials Science and Engineering C, vol. 105, no. , 2019, pp. -.
APA	Kalantari E, Naghib SM, Iravani NJ, Esmaeili R, Naimijamal MR, Mozafari M (2019). Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies. Materials Science and Engineering C, 105(), -.
Chicago	Kalantari E, Naghib SM, Iravani NJ, Esmaeili R, Naimijamal MR, Mozafari M. "Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies." Materials Science and Engineering C 105, no. (2019): -.
Harvard	Kalantari E et al. (2019) 'Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies', Materials Science and Engineering C, 105(), pp. -.
Vancouver	Kalantari E, Naghib SM, Iravani NJ, Esmaeili R, Naimijamal MR, Mozafari M. Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies. Materials Science and Engineering C. 2019;105():-.
BibTex	@article{ author = {Kalantari E and Naghib SM and Iravani NJ and Esmaeili R and Naimijamal MR and Mozafari M}, title = {Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies}, journal = {Materials Science and Engineering C}, volume = {105}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Kalantari E AU - Naghib SM AU - Iravani NJ AU - Esmaeili R AU - Naimijamal MR AU - Mozafari M TI - Biocomposites Based on Hydroxyapatite Matrix Reinforced With Nanostructured Monticellite (Camgsio4) for Biomedical Application: Synthesis, Characterization, and Biological Studies JO - Materials Science and Engineering C VL - 105 IS - SP - EP - PY - 2019 ER -

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