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Nanostructured Monticellite: An Emerging Player in Tissue Engineering Publisher



Kalantari E1, 2 ; Naghib SM1 ; Naimijamal MR2 ; Esmaeili R3 ; Majidzadeha K3, 4 ; Mozafari M5
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Authors Affiliations
  1. 1. Nanotechnology Department, School of New Technologies, Iran University of Science and Technology (IUST), Tehran, Iran
  2. 2. Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology (IUST), Tehran, Iran
  3. 3. Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Faculty of Medicine, Tasnim Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran
  5. 5. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran

Source: Materials Today: Proceedings Published:2018


Abstract

Several types of calcium silicates have been significantly investigated for hard tissue engineering and replacement owing to their great potential for repair and regeneration. Here, a novel calcium silicate bioceramic (monticellite) was synthesized by sol-gel method and heat-treated at low temperature (1350°C). After physico-chemical characterization of the prepared bioceramic, bioactivity assessment was conducted via immersing in simulated body fluid (SBF) for investigating the apatite forming ability. The results exhibited that an apatite-like layer has formed on the surface of SBF-soaked sample after 14 days. In vitro evaluations showed that monticellite is biocompatible over mouse osteoblast-like cells (G292). In fact, the results shown that the monticellite bioceramics with good bioactivity had the ability G292 cell growth at a certain concentration range and exhibited good cytocompatibility. © 2018 Elsevier Ltd.
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