Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19

Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19 Publisher Pubmed

Sahebi L¹ ; Hosseini M² ; Abdollahi A³ ; Farrokhzad N¹ ; Fattah Ghazi S⁴ ; Samaei Noroozi F⁵ ; Ghiasvand F⁶

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1. Maternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Science, Tehran, Iran
2. School of Medicine, Tehran University of Medical Science, Tehran, Iran
3. Department of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Anesthesiology and Critical Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
5. Central Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Microbiology Published:2022

Abstract

Objective & aim: The coronavirus disease, so far (COVID-19) has brought about millions of infections and fatalities throughout the world. Our aim was to determine the correlation between rubella IGG titers with the severity COVID-19. Materials & methods: This study was conducted among COVID-19 confirmed patients over 18 years of age. The disease severity levels were categorized by WHO interim guidance. The rubella-specific IgG antibody-titer spectrum was measured (within first 48 h of hospitalization) by enzyme-linked immunosorbent assay (ELISA). Result: In a study of 46 inpatients with varying COVID-19 disease severity (mild, moderate, severe, and critical), we observed a negative correlation between rubella IgG antibody titers and COVID‐19 severity (P-Value = 0.017), There was an interaction between COVID-19 vaccination history and rubella IGG on severity COVID-19 (P-Value = 0.0015). There was an interaction between age group under 44 years (including national measles- rubella (MR) vaccination in Iran) and rubella IGG titers on severity COVID-19 too (p-value = 0.014). Conclusion: In conclusion, MR vaccination seems to have a positive effect in reducing the severity of the disease, emphasizing that, the important and separate effect of the IGG rubella (due to natural or extrinsic immunity) titers is determining. © 2022, The Author(s).

2. Does Prior Immunization With Measles, Mumps, and Rubella Vaccines Affect the Antibody Response to Covid-19 Antigens?, Iranian Journal of Immunology (2021)

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Style	Citing Format
MLA	Sahebi L, et al.. "Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19." BMC Microbiology, vol. 22, no. 1, 2022, pp. -.
APA	Sahebi L, Hosseini M, Abdollahi A, Farrokhzad N, Fattah Ghazi S, Samaei Noroozi F, Ghiasvand F (2022). Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19. BMC Microbiology, 22(1), -.
Chicago	Sahebi L, Hosseini M, Abdollahi A, Farrokhzad N, Fattah Ghazi S, Samaei Noroozi F, Ghiasvand F. "Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19." BMC Microbiology 22, no. 1 (2022): -.
Harvard	Sahebi L et al. (2022) 'Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19', BMC Microbiology, 22(1), pp. -.
Vancouver	Sahebi L, Hosseini M, Abdollahi A, Farrokhzad N, Fattah Ghazi S, Samaei Noroozi F, et al.. Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19. BMC Microbiology. 2022;22(1):-.
BibTex	@article{ author = {Sahebi L and Hosseini M and Abdollahi A and Farrokhzad N and Fattah Ghazi S and Samaei Noroozi F and Ghiasvand F}, title = {Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19}, journal = {BMC Microbiology}, volume = {22}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Sahebi L AU - Hosseini M AU - Abdollahi A AU - Farrokhzad N AU - Fattah Ghazi S AU - Samaei Noroozi F AU - Ghiasvand F TI - Does the Rubella Immunoglobulin G Affect the Severity of Covid- 19? : Rubella Immunoglobulin G and Covid- 19 JO - BMC Microbiology VL - 22 IS - 1 SP - EP - PY - 2022 ER -

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