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Quinidine Publisher



Lashgari NA1 ; Shayan M2, 3 ; Shamsnia H1, 4 ; Roudsari NM1 ; Momtaz S4, 5, 6 ; Abdolghaffari AH1, 4
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Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

Quinidine is an alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. Quinidine is an alpha-adrenergic antagonist, an antimalarial, an anti-arrhythmia drug, a sodium channel blocker, a muscarinic antagonist, a potassium channel blocker, a P450 inhibitor, an EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor, and a drug allergen. In this chapter, we discussed the pharmacological aspects of quinidine, and its exposure guidelines, kinetics and toxicities. © 2024 Elsevier Inc. All rights reserved.