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Synthesis of a New 1,2,3-Triazoles Scaffold Using a Heterogeneous Multifunctional Copper Photocatalyst for in Vitro Investigation Via Click Reaction Publisher



Mohammadkhani A1 ; Hosseini S2, 4 ; Pourmousavi SA2 ; Heydari A1 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. Chemistry Department, Tarbiat Modares University, Tehran, Iran
  2. 2. School of Chemistry, Damghan University, Damghan, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Central Research Laboratories, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Catalysis Science and Technology Published:2024


Abstract

In this work, a new ternary-layered double-hydroxide photocatalyst, denoted as Fe3O4/AlZn-Cu, was synthesized using a specific 6.5 : 3 : 7.5 : 1.5 mol mol−1 ratio. The rational selection of constituents in this catalyst - Fe3O4 for bulk and electron richness effect, AlZn LDH for supporting the photo redox process, and copper as an active site - is thoroughly elucidated. This paper comprehensively investigates the synthesis and characterizes the properties of this magnetic ternary-layered double-hydroxide heterogeneous multifunctional photocatalyst. Several key scientific domains are explored within this study: (i) demonstrating the catalyst's efficacy in synthesizing 1,2,3-triazoles N-acetamide as an active biological candidate; (ii) synthesize a 1,2,3-triazole scaffold in a benign and ambient environment, having biologically active properties (iii) a comprehensive analysis of the catalyst's structural, optical, and electrochemical properties; and (iv) evaluating the potential of newly structured drug candidates, integrating two anti-Alzheimer heterocyclic moieties linked through click chemistry, through in vitro assessment. Employing insights from biorthogonal chemistry, this study establishes a link between two distinct active Alzheimer-targeting biological moieties via click chemistry, obviating the need for organic ligands, photosensitizers, and additives. Furthermore, the multifunctional photocatalyst proves to be cost-effective, robust, and recyclable. The stability of the Fe3O4/AlZn-Cu structure allows for efficient recyclability, facilitated by magnetic recovery techniques, demonstrated effectively over five cycles. Extensive analysis of the recycled catalyst is conducted, affirming its potential for sustainable applications. © 2024 The Royal Society of Chemistry.