Efficient Synthesis of 3-Alkyl-2-(-1H-1,2,3-Triazolyl)Methyl)Thio)-2,3-Dihydroquinazolin-4(1H)-One Derivative Via Multistep Synthesis Approach by Novel Cu@Py-Oxa@Spion Catalyst Publisher



Sherafati A¹ ; Moradi S¹ ; Mahdavi M² Show Affiliations
Source: BMC Chemistry Published:2023

Abstract

In this pared, an efficient method is introduced for the synthesis of 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives. These novel products have both 1,2,3-triazole and quinazolinone in their structures. For the synthesis of these products, a novel catalyst is designed, synthesized, and characterized by the immobilization of copper onto modified magnetic iron oxide. The catalyst (denoted: Cu@Py-Oxa@SPION) was characterized by several characterization techniques. In this regard, 16 3-alkyl-2-(((4-(2-oxopropyl)-1H-1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized in high isolated yields (77–86%). As an advantage, the catalyst is highly recoverable and its activity has not decreased after 7 sequential runs. The method is very efficient for the synthesis of the products in high isolated yields under mild reaction conditions in a green solvent. The scope of the method is broad and several examples were successfully synthesized using starting materials with different functional groups. © 2023, The Author(s).